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2009 NOV 16 ... insights into multiple events simultaneously involving both c-Jun and HIF-1 alpha in tumor progression. [Cancer Res 2009;69(19):7704-12]." Yu and colleagues ... "Although hypoxia-inducible factor-1 alpha (HIF-1 alpha) has long been intensively investigated as a drug ...
2009 NOV 9 ... was not associated with inhibition of cerebral cytokine production. We investigated how tumor necrosis factor-alpha (TNF-alpha) production is maintained after NF-kappa B inhibition ... damage. Postnatal Day 7 rats were subjected to unilateral carotid artery occlusion and hypoxia. Rats were treated immediately after HI with TAT-NBD, the JNK inhibitor TAT-JBD, and/or ...
2009 NOV 23 ... Arthritis, Hyperplasia, Oncology, Osteoarthritis, Rheumatism, Rheumatoid Arthritis, Tumor Vascularization, VEGF, Vascular Endothelial Growth Factor. This article was ... studies. The role of vascular endothelial growth factor (VEGF), CXCL12, and hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha) in these processes was investigated ...
2009 NOV 16 ... KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced ... According to recent research from the United States, "Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular response to low oxygen, ...
2009 NOV 16 ... simultaneously determined. Application of this modality to murine tumors revealed that tumor regions with high vascular permeability were spatio- temporally coincident with hypoxia. ...
2009 NOV 3 ... specific prolyl residue (Pro850) in the ODDD, and the activity of the von Hippel Lindau tumor suppressor factor. At high oxygen tension rapid nuclear export of Sima occurs, whereas ... factor. At high oxygen tension rapid nuclear export of Sima occurs, whereas in hypoxia, Sima nuclear export is largely inhibited," wrote M. Irisarri and colleagues, ...
2009 NOV 9 ... pathway is essential for cell survival under low oxygen and plays an important role in tumor cell homeostasis. We investigated the function of miR-210, the most prominent microRNA ... According to recent research from the United States, "The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen and plays ...
2009 NOV 23 ... in the number of viable tumor cells and FDG consumption. Although Surrogate markers for tumor hypoxia and acidity showed a trend for correlation with increased glycolysis in pretreated stage ...
2009 NOV 23 ... Here, we identify HIF-2 alpha as a marker of normoxic neural crest-like neuroblastoma tumor-initiating/stem cells (TICs) isolated from patient bone marrows," scientists in Malmo, ... "High hypoxia-inducible factor-2 alpha (HIF-2 alpha) protein levels predict poor outcome in ...
2009 NOV 23 ... (44/53) were stained positive for DEC1. The DEC1 expression was increased during the tumor progression from well differentiated (50%, 4/8) to moderately differentiated (76%, ... published the results of their research in Omics - a Journal of Integrative Biology (The Hypoxia-Regulated Transcription Factor DEC1 (Stra13, SHARP-2) and Its Expression in Gastric ...
2009 NOV 25 ... certain extent from rapid dual-tracer Cu-62 - PTSM (blood flow) + Cu-62 - ATSM (hypoxia) tumor imaging.""In this work, the feasibility of rapidly imaging F-18-FDG plus ...
2009 NOV 16 ... seems to be involved also in angiogenesis. Since both processes are closely linked with tumor metastasis this study investigated the expression of VEGFR-3 in tumor-associated vessels ... are more realistic for the tumor situation, the levels remained unchanged. In contrast, hypoxia exposure of macrovascular human umbilical vein endothelial cells (HUVEC) led to a ...
2009 NOV 16 ... enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor in several human cancers," researchers in Florence, Italy ...
2009 NOV 16 ... "Vascular disrupting agents (VDA) cause acute shutdown of abnormal established tumor vasculature, followed by massive intratumoral hypoxia and necrosis. However, a viable ...
2009 NOV 16 ... increased with NAFLD progression. Increased expression of proinflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta was observed and may be responsible for ... Furthermore, elevated CYP2C9 activity during NAFLD progression correlated with elevated hypoxia-induced factor 1 alpha expression in the later stages of NAFLD," wrote C.D. Fisher and ...
2009 NOV 16 ... Kiel, Angiogenesis, Enzymes, Kinase, Oncology, Ophthalmology, Therapy, Treatment, Tumor Vascularization, Vascular Endothelial Growth Factor. This article was ... but its expression is upregulated by various (noxious) stimuli, e.g. oxidative stress or hypoxia. Discrimination between constitutive expression of VEGF and its pathological ...
2009 NOV 16 ... "Pretreatment of mice bearing prostate cancer xenografts with acriflavine prevented tumor growth and treatment of mice bearing established tumors resulted in growth arrest. ... "HIF-1 is a heterodimeric transcription factor that mediates adaptive responses to hypoxia and plays critical roles in cancer progression. Using a cell-based screening assay we ...
2009 NOV 16 ... almost universally fatal. A deeper understanding of the molecular relationship of these tumor types is necessary to derive insights into the diagnosis, prognosis, and treatment of ... multiple testing out of > 175 pathways examined. The most significant pathway was the hypoxia-inducible factor (HIF) pathway. Our analysis suggests that many of the most ...
2009 NOV 9 ... cell carcinoma (HNSCC) represents an ideal model for assessing the impact of anemia and tumor hypoxia on the response to radiotherapy (RT). Various treatment strategies aimed at increasing ...
