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2009 NOV 30 ... Levine is one of the key individuals credited with the discovery of the protein p53 as a tumor suppressor, and his research has been cited as a new paradigm in cancer research. ... work from 1979 described above. The Levine lab made the first discovery of DNA virus proteins interactions with host proteins such as p53, and the Harlow lab described the ...
2009 DEC 1 ... information, contact K. Takada, Hokkaido University, Institute Med Genetics, Dept. of Tumor Virology, Sapporo, Hokkaido 0600815, Japan. The publisher's contact ... "The Epstein-Barr virus (EBV) immediate-early transactivator BZLF1 plays a key role in switching EBV infection ...
2009 NOV 23 ... C1q was not specific for IFN alpha but was also seen for interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha. We demonstrated binding of C1q to PDCs both by surface plasmon ... IFN alpha production induced by RNA-containing immune complexes (ICs), herpes simplex virus (HSV), and CpG DNA. C1q also inhibited PDC IFN alpha production induced by ICs and CpG ...
2009 NOV 24 ... "Reconstitution of the glucocorticoid receptor (GR)-regulated mouse mammary tumor virus (MMTV) promoter in Xenopus oocytes was used to monitor the effects of different ...
2009 NOV 23 ... families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and ... gene expression, and viral DNA synthesis to levels normally observed during wildtype virus infection of quiescent cells. UL97-null mutants exhibited more pronounced defects in ...
2009 NOV 23 ... "All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed. In humans in two cases hepatitis B virus (HBV) and in one case ...
2009 NOV 30 ... adjacent mucosa. There was no clear relationship between expression of HPV 16 E6/E7 and tumor stage, prognosis or the positive rate of p53 abnormality," wrote Y. Yamakawakakuta and ... "Human papilloma virus (HPV) has been recently proposed to be implicated in the development of head and neck ...
2009 NOV 23 ... (AIDS diagnosis and/or CD4+ < 500 cells/mm(3)) did not appear to correlate with tumor grade, stage, or an adverse outcome. These data show that HIV-infected patients with ... "Patients infected with Human immunodeficiency virus (HIV) living longer with antiretroviral therapy (ART) are more likely to develop ...
2009 NOV 30 ... virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated tumor regression. Although the ability of oncolytic viruses to generate adaptive antitumor ... Activity, Immunology, Melanoma, Reoviridae, Reovirus, Treatment, Viral, Virology, Virus This article was prepared by Biotech Business Week editors from staff and ...
2009 NOV 23 ... T cells and induced cytotoxic T lymphocytes (CTLs) which effectively eradicated the tumor from mice," investigators in Moroyama, Japan report. "In this study, we ... to immunodominant CTL epitope peptides derived from lymphocytic choriomeningitis virus (LCMV) and evaluated its potency as an antiviral vaccine. The intramuscular immunization ...
2009 NOV 30 ... HBV infection (P=.009; odds ratio, 1.79; 95% confidence interval, 1.15-2.78) and poor tumor differentiation (P <.001; odds ratio, 2.01; 95% confidence interval, 1.36-2.96). The ... "The role of hepatitis B virus (HBV) infection in determining the prognosis after hepatectomy for hepatocellular ...
2009 NOV 30 ... trastuzumab-bound lentivirus expressed luciferase, although the latter route was less tumor specific. When a prostate-specific promoter for governing luciferase expression was ... Proteins, Proteomics, Thymidine Kinase, Trastuzumab, Treatment, Viral, Virology, Virus This article was prepared by Anti-Infectives Week editors from staff and ...
2009 NOV 24 ... information, contact K. Takada, Hokkaido University, Institute Med Genetics, Dept. of Tumor Virology, Sapporo, Hokkaido 0600815, Japan. The publisher's contact ... to recent research published in the Journal of Experimental Medicine, "Epstein-Barr virus-encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop ...
2009 NOV 23 ... 218 (37.9%) underwent LT and 115 (20%) were removed from the list (76 deaths, 25 tumor progressions, and 14 sick conditions). The 1- and 3-year survival rates on the list were ... These two variables had no impact on survival after LT, except in hepatitis C virus positive recipients. The multivariate Cox model confirmed a positive transplant benefit ...
2009 NOV 23 ... approximately 6 months, despite therapy." "Identification of the primary tumor site may offer the opportunity of a specific and more efficient treatment. The case of a ... The researchers concluded: "As the presented case illustrates, testing for this virus DNA in human tissues can be a useful diagnostic tool in patients with CUP where cervical ...
2009 NOV 30 ... being treated with pSIALR-A and anti-hALR McAb was detected. The growth of the xenograft tumor was observed after being treated with pSIALR-A and anti-hALR McAb in nude mice. We ... Regeneration, Monoclonal Antibodies, Oncology, Tissue Engineering, Viral Hepatitis, Virus This article was prepared by Biotech Business Week editors from staff and ...
2009 NOV 23 ... transrenal DNA/RNA technology which include assays to detect mutations in solid tumor cancers and organisms that cause infectious diseases. We will pursue a combined ... has filed a patent application on novel technology for the detection of Human Papilloma Virus (HPV) DNA, based on Xenomics transrenal DNA technology. The technology would be applied ...
