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2009 JAN 26 ... immunity in colorectal cancer, we evaluated the efficacy of intrarectal recombinant vacciniavirus expressing the human carcinoembryonic Ag (CEA) in a murine FAP model in which mice ... Colon Carcinoma, Colorectal, Endocrinology, Gastroenterology, Gene Therapy, Genetics, Genomics, Immunization, Immunology, Oncology, Physiology, Tumor Suppression, Vaccination, ... mucosa contains an intact immune system that protects the host from pathogens and communicates with the systemic immune system. Absorptive epithelial cells in the mucosa ...
2009 OCT 12 ... Fresh data on vacciniavirus are presented in the report 'The highly attenuated oncolytic recombinant vaccinia ... Zhang and colleagues published their study in Molecular GeneticsandGenomics (The highly attenuated oncolytic recombinant vaccinia virus GLV-1h68: comparative ...
2009 JUL 20 ... and persistence. The purpose of this study was to determine if a genetically modified vacciniavirus, GLV-1h99, containing a human norepinephrine transporter (hNET) reporter gene, ... New York, Antiviral, Cancer Research, Experimental Design, Gastroenterology, Genetics, Genomics, Malignant Mesothelioma, Mesothelioma, Oncology, Pancreas, Pancreatic Cancer, Pancreatic ...
2009 MAY 12 ... According to a study from the United States, "Vacciniavirus intermediate and late class transcriptional promoters each have two essential ... CA 92101-4495, USA.
Keywords: United States, West Lafayette, Genetics, Genomics, Reporter Gene, Vaccinia Virus, Virology, Purdue University.
This article ...
2009 NOV 2 ... Scientists discuss in 'Lister strain of vacciniavirus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for ... Cancer Gene Therapy, Cancer Vaccines, Drug Development, Gastroenterology, Genetics, Genomics, Immunization, Oncology, Pancreas, Pancreatic Cancer, Pancreatic Carcinoma, Pancreatic ... "Survival after pancreatic cancer remains poor despite incremental advances in surgical and adjuvant therapy, and new strategies for treatment are needed. Oncolytic virotherapy is ...
2009 AUG 3 ... Orthologs of G1R are present in a variety of pathogenic orthopoxviruses, but not in vacciniavirus, and expression of any one of these viral proteins blocks NF-kappa B signaling in ... USA. Keywords: United States, Gainesville, Biotechnology, DNA Libraries, Genomics, Protein Interaction, Proteins, Proteomics, Smallpox, Variola Virus, Viral Research, ... contact M.R. Mohamed, University of Florida, College Medical, Dept. of Molecular Genetics & Microbiology, Gainesville, FL 32610, USA. The publisher's contact ...
2009 NOV 16 ... in the cytoplasm of the host cell. In this context, we investigated the function of the vacciniavirus G5 protein because it belongs to the FEN1-like family of nucleases and is ... Keywords: United States, Bethesda, Allergies, Allergy Medicine, DNA, Enzymes, Genetics, Genomics, Infectious Diseases, Nuclease, Vaccinia, Vaccinia Virus, Virology, National Institute ...
2008 JUN 23 ... "The vacciniavirus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that ... Keywords: United States, Birmingham, Antiviral, Enzyme Research, Genetics, Genomics, Treatment, Triphosphatase, Vaccinia Virus, Viral Inhibition, Viral Therapy, Virology, ... deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome. ...
2008 SEP 22 ... "Vacciniavirus has recently been used as an expression vector for gene delivery and an oncolytic ... Apoptosis, Biotechnology, Cancer Gene Therapy, Enzyme Research, Enzymology, Genetics, Genomics, Interferon, Kinase, Oncology, Protein Kinase C, Proteins, Proteomics, Rnase, Treatment, ...
2008 DEC 8 ... by a FAM (6-carboxyfluorescein)-labeled probe while camelpox, cowpox, monkeypox andvaccinia viruses could be detected by a TET (6-carboxytetramethylrhodamine)-labeled probe in a ... chain reaction (PCR) assay based on dried PCR reagents was developed. Only variola virus could be specifically detected by a FAM (6-carboxyfluorescein)-labeled probe while ... States, Frederick, Cowpox, DNA, Diagnosis, Diagnostics, Enzyme Research, Genetics, Genomics, Polymerase, Smallpox, Vaccinia Virus, Variola Virus, Viral Research, Virology.
...
2008 JUL 7 ... Research findings, 'Determinants of vacciniavirus early gene transcription termination,' are discussed in a new report. "Vaccinia ... United States, Buffalo, Biotechnology, Enzyme Research, Gene Therapy, Genetics, Genomics, Phosphohydrolase, Polymerase, Treatment, Vaccinia Virus, Virology.
This ... VTF, nucleoside triphosphate phosphohydrolase I, NPH I, ATP, the virion RNA polymerase, and the motif, UUUUUNU, in the nascent RNA, found within 30 to 50 bases from the poly A ...
2008 JUL 7 ... essential for orthopoxvirus replication, were investigated for their ability to inhibit vacciniavirus strain Western Reserve (VACVWR) replication. Among these siRNAs, 100 nM siD5R-2, ... Gene Therapy, Biotechnology, Bioterrorism, Biowarfare, Cancer Gene Therapy, Genetics, Genomics, Lung Cancer, Lung Carcinoma, Oncology.
This article was prepared by ... novel antiviral treatments. Currently, there are no effective therapies against smallpox and new treatment strategies are greatly needed."
"In this study, ...
2008 NOV 17 ... a median survival of less than 14 months. For the first time, a genetically engineered vacciniavirus is shown to produce efficient infection, replication, and oncolytic effect against ... Enzyme Research, Enzymes, Enzymology, Galactosidase, Gene Therapy, Genetics, Genomics, Glucuronidase, Kinase, Luciferase, Mesothelioma, Pharmaceuticals, Proteins, Proteomics, ...
2008 JUN 23 ... Fresh data on vacciniavirus are presented in the report 'Phenotypic analysis of a temperature sensitive ... Biochemical, Biotechnology, DNA, DNA Replication, DNA Research, Gene Therapy, Genetics, Genomics, Medical Device, Treatment, Vaccinia Virus, Virology.
This article was ... vaccinia virus mRNA capping enzyme is a multifunctional enzyme, encoded by genes D1R and D12L. Published biochemical experiments demonstrate that, in addition to mRNA capping, ...
2008 SEP 15 ... replication of H5N1 and H1N1 influenza A viruses, but not vesicular stomatitis virus or vacciniavirus, in human HEK 293 cells. Thus, we have demonstrated the feasibility of using ... Antiviral, Biotechnology, Drug Development, Enzymology, Flu, Gene Therapy, Genetics, Genomics, Immunization, Influenza, Influenza Virus, Luciferase, Pharmaceuticals, Proteomics, RNA ...
2008 DEC 15 ... to a study from Strasbourg, France, "We have generated a thymidine kinase gene-deleted vacciniavirus (VV) (Copenhagen strain) that expressed the fusion suicide gene FCU1 derived from ... Research, Enzymes, Enzymology, Fluorocytosine, Fluorouracil, Gastroenterology, Genetics, Genomics, Kinase, Mental Health, Oncology, Pharmaceuticals, Phosphoribosyltransferase, Proteins, ... that expressed the fusion suicide gene FCU1 derived from the yeast cytosine deaminase and uracil phosphoribosyltransferase genes. Intratumoral inoculation of this thymidine ...
