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2009 NOV 16 ... heavily pretreated patients with resistant and refractory CML and Philadelphia-positive acute lymphoblastic leukemia, including those with the T315I mutant variant of the target ... pan-BCR-ABL inhibitor, AP24534, in patients with drug-resistant and refractory chronic myeloid leukemia (CML) and other hematological cancers at the upcoming American Society of ...
2009 NOV 16 ... and is now in a Phase 1 dose-escalating clinical trial in patients with refractory CML, acute myeloid leukemia (AML) and other hematological malignancies. "These data support the ...
2009 NOV 23 ... product candidate, for the treatment of patients with Chronic Myeloid Leukemia (CML), Acute Myeloid Leukemia (AML), and Myelodysplastic Syndrome (MDS). A New Drug Application has been submitted to ...
2009 NOV 16 ... "A Phase 1 study of ENMD-2076 in patients with relapsed or refractory acute myeloid leukemia (AML)," Halls C-D, 2nd floor. -- Poster Session: Monday, November 16, ...
2009 NOV 17 ... HCT from unrelated donors between 2000 and 2007." "Thirty-five had acute myeloid leukemia, and 21 had acute lymphoid leukemia. Stem cell sources included bone marrow in 38, ...
2009 NOV 23 ... "Phlegmonous gastritis is a rare acute bacterial infection of the gastric wall with an extremely high mortality rate. Early ... researchers concluded: "Immunohistochemical studies further revealed the occurrence of myeloid sarcoma that involved the gastrointestinal tract." Guo and colleagues ... "Here we report a case in which a patient with underlying chronic myelomonocytic leukemia was diagnosed with phlegmonous gastritis on biopsy. This 57-year-old man presented with ...
2009 NOV 23 ... miRNAs with myelodysplastic syndromes (MDS) and MDS progression to acute myeloid leukemia (AML)." "We assessed 25 mature miRNAs in total RNA from bone marrow (BM) ...
2009 NOV 16 ... with imatinib-resistant and -intolerant CML and Philadelphia chromosome-positive acute lymphoblastic leukemia. Nilotinib, an analog of imatinib, more potent than its parent ... of the BCR-ABL inhibitor imatinib revolutionized the treatment of patients with chronic myeloid leukemia (CMIL). However, resistance to imatinib has become a clinically significant ...
2009 NOV 23 ... "We previously found that epidermal growth factor receptor (EGFR) inhibitors induce acute myeloid leukemia (AML) differentiation via a non-EGFR mechanism. In this report, we integrated proteomic ...
2009 NOV 23 ... and could have a role in the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). Indeed, recent studies showed that phosphoinositide-phospholipase (PI-PL) Cbeta1 ...
2009 NOV 23 ... Research findings, 'Mitoxantrone and etoposide in patients with newly diagnosed acute myeloid leukemia with persistent leukemia after a course of therapy with cytarabine and idarubicin,' are ...
2009 NOV 16 ... at high levels in, and is required for the proliferation of, most human myeloid and acute lymphoid leukemias," scientists in Australia report. "Recently, ... and genomic duplications of c-MYB have been identified in human T-cell acute leukemia. The present work focuses on the effects of mutations in different domains of the murine ...
2009 NOV 16 ... Nuclear Medicine, "Isolated extramedullary relapse with involvement of the breasts by acute myeloid leukemia (AML) after allogeneic stem cell transplantation is an,uncommon event. We here report ...
2009 NOV 23 ... evidence of voreloxin's synergistic and additive effects when combined with other acute myeloid leukemia (AML) treatments, supporting the current combination study and identifying potential ...
2009 NOV 16 ... Drug Administration has granted voreloxin orphan drug designation for the treatment of acute myeloid leukemia (AML). Sunesis is currently conducting two Phase 2 clinical trials of voreloxin in AML: ...
2009 NOV 9 ... According to recent research from Netherlands, "Acute myeloid leukemia (AML) has a different clinical and biologic behavior in patients at older age. To gain ...
2009 NOV 16 ... up to 15,000 people each year in the United States, and that sometimes results in acute myeloid leukemia. Researchers found that the gene RhoB is important to the disease's progression and ...
