Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Google 2009 PageRank: #2 Among Top Health News and Media Publications
Google 2009 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2009 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2009 PageRank: #2 News and Media Site for the Pharmaceutical Industry
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
2009 NOV 24 ... in the regulation of apoptosis in leukocytes. Depending on the cell type, pro- and antiapoptotic effects of cAMP have been described," investigators in Essen, Germany report. ...
2009 NOV 16 ... activation of caspase-3 and its downstream target, PARP cleavage. The protein level of antiapoptotic bcl-2 was also reduced by Ce-6-PDT in RK3E-ras cells. In in vivo experiments, ...
2009 NOV 23 ... fluid. In cellular assays, OPN-FL, and to a lesser extent OPN-R and OPN-L, had an antiapoptotic effect on neutrophils. OPN-R augmented RA fibroblast-like synoviocyte binding mediated ...
2009 NOV 23 ... According to a study from Parkville, Australia, "Bcl-xL is an antiapoptotic member of the Bcl-2 family of proteins and a potent regulator of cell death. We ...
2009 NOV 23 ... cellular responses; however, the EGFR pathway was independent of the NF-kappa B antiapoptotic pathway," wrote M. Nishimura and colleagues, Toyama University. The ...
2009 NOV 16 ... cells. In contrast to unspecific LipofectAMINE transfection, down-regulation of antiapoptotic bcl-2 using fusion protein complexed siRNA was strictly dependent on EpCAM binding and ...
2009 NOV 16 ... world blindness-are potentially treatable by using low-molecular weight neuroprotective, antiapoptotic, or antineovascular drugs. These agents are, however, not in current systemic use owing ...
2009 NOV 16 ... receptor (IGF1R) are receptor tyrosine kinases that participate in mitogenic and antiapoptotic signaling in normal and neoplastic epithelia. In the present study, immunoblotting and ...
2009 NOV 16 ... oxygen species (ROS) production. TGF-beta-induced NOX4 expression is inhibited by antiapoptotic signals, such as the phosphatydilinositol-3-phosphate kinase or the mitogen-activated ...
2009 NOV 16 ... PI3K/Akt activation induces cell survival as suggested by the stimulation of the antiapoptotic factor Bcl-2. ERK1/2 activation results in up-regulation of IL-8 expression, an effect ...
2009 NOV 16 ... has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refractory prostate cancer and increased following ...
2009 NOV 16 ... of the myometrium. We previously identified endothelin (ET)-1 as a proliferative and antiapoptotic factor in Eker rat-derived leiomyoma (ELT3) cells," scientists writing in the journal ...
2009 NOV 9 ... death domain protein (FADD), phosphorylated-FADD, and caspase 8 and 10, and the antiapoptotic protein bcl-2. We studied pathway integrity and relations to risk and clinical factors, ...
2009 NOV 9 ... function is attributed to two distinct mechanisms which both rely on PUMA binding to the antiapoptotic BCL-2 proteins: de-repression and sensitization," wrote J.E. Chipuk and colleagues, ...
2009 NOV 9 ... B in primary cardiac cells inhibits Dox-mediated apoptosis and prevents the loss of the antiapoptotic protein Bcl-2. Specific silencing of CaMKII delta B by small interfering RNA prevents ...
2009 NOV 16 ... The researchers concluded: "DA afforded short- and long-term cardioprotective effects. Antiapoptotic effects, through the activation of Akt that regulates the Bcl-2 family proteins and ...
2009 NOV 24 ... expression, both in vivo and in vitro, disrupted interactions between proapoptotic and antiapoptotic factors, and suppressed H2O2-induced loss of mitochondrial membrane potential in vitro. ...
2009 NOV 16 ... the PGRMC1-deplete cells grew slower in vitro and did not show progesterone's (P4) antiapoptotic effect," scientists in the United States report. "In fact, P4 induced ...
2009 NOV 9 ... miR-135-amediated JAK2 down-regulation led to decreased mRNA and protein levels of the antiapoptotic gene Bcl-xL, suggesting a role for Bcl-xL in miR-135a/JAK2-mediated apoptosis," wrote ...
2009 NOV 16 ... of the proto-oncogene c-myc, in a functional yeast survival screen for tumor-related antiapoptotic proteins and demonstrated strong overexpression of FBP1 in human hepatocellular ...
