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2009 NOV 16 ... were incubted with metformin, insulin, or combined metformin and insulin treatment, and aromatase mRNA expression was quantified using real-time RT-PCR. Enzyme activity was assessed by ... phosphorylated, and total ERK-1,2 from cells cultured as above with/without the MEK inhibitor PD98059. Metformin significantly inhibited basal and insulin-stimulated aromatase mRNA ...
2009 NOV 2 ... ERalpha-positive primary breast cancer were treated daily with 25 mg of exemestane (an aromatase inhibitor) for 6 months. Expressions of ERalpha, ERbeta, progesterone receptor (PgR), androgen ...
2009 NOV 16 ... a single agent in third-line therapy. It is also approved for use in combination with an aromatase inhibitor for the treatment of post-menopausal patients with HER2 and hormone receptor co-positive ...
2009 SEP 28 ... late normal gestation (i.e., Day 165; term is 184 days) and in baboons administered the aromatase inhibitor letrozole throughout the second half of gestation to assess the impact of endogenous ...
2009 SEP 28 ... women with advanced breast cancer progressing or recurring after prior non-steroidal aromatase inhibitor therapy. Overall, approximately 57% of patients in EFECT had visceral involvement. ...
2009 NOV 1 ... study was to investigate the possible role of oestrogen in schizophrenia by comparing aromatase knockout (ArKO) mice, which are unable to produce oestrogen, with wild-type controls ... USA. Keywords: Australia, Melbourne, Adrenergic Agent, Adrenergic Uptake Inhibitor, Amphetamine, Antidyskinetic, Antiparkinson, Apomorphine, Central Nervous System ...
2009 OCT 5 ... anorexia and bleeding. About Aromasin® (exemestane tablets) Aromasin is the only aromatase inhibitor indicated for sequential therapy in postmenopausal women with HR positive early breast ...
2009 NOV 23 ... positive, non-metastatic breast cancer and low bone mass who were receiving adjuvant aromatase inhibitor therapy. In subgroup analyses at 12 and 24 months, we evaluated factors (duration and ...
2009 OCT 19 ... the effects of both estradiol and androgens on telomerase function, and letrozole, an aromatase inhibitor, blocked androgen effects on telomerase activity. Conversely, flutamide, an androgen ...
2009 SEP 28 ... at baseline with progressive metastatic breast cancer on tamoxifen followed by an oral aromatase inhibitor (AI)," investigators in Leuven, Belgium report. "Fulvestrant (250 mg) was ...
2009 NOV 23 ... mice were implanted with endometrial carcinoma. Some tumor-laden mice were treated with aromatase inhibitor letrozole and/or curcumin. The tumor growth was monitored. Tumor cell apoptosis was ...
2009 NOV 16 ... BC defined as HR-positive BC with progression after treatment with tamoxifen and an aromatase inhibitor. Group 2 had HR-negative BC. Tumor response was assessed every 8 weeks. The primary end ...
2009 SEP 28 ... "Domestic pigs have three CYP19 genes encoding functional paralogues of the enzyme aromatase cytochrome P450 (P450arom) that are expressed in the gonads, placenta, and ... Hypothalamic tissue synthesized 1OH-T and was sensitive to the selective P450arom inhibitor etomidate. Levels were 4-fold higher in male than female hypothalami, with expression in ...
2009 SEP 28 ... University of Glasgow. The researchers concluded: "Implementing an aromatase inhibitor after an initial 2-3 years of tamoxifen fails to address this early peak of distant ...
2009 SEP 28 ... 59 in one patient preference cohort study, and 90 in a randomized controlled trial. An aromatase inhibitor was used in two of the non-comparative studies, vaginal danazol in one, a GnRH agonist ...
2009 NOV 2 ... letrozole-induced embryopathic effects.' According to a study from Chieti, Italy, "The aromatase inhibitor, letrozole, exerts embryo toxic effects in rats, causing increased embryo lethality and ...
2009 OCT 5 ... The TEAM study is a randomised phase III clinical trial comparing the efficacy of the aromatase inhibitor exemestane versus the current "gold standard" treatment tamoxifen as adjuvant ...
2009 OCT 5 ... of any trial to date investigating the impact of switching from tamoxifen to an aromatase inhibitor, involved 4,724 postmenopausal women from 37 countries with oestrogen-receptor-positive ...
2009 OCT 5 ... progesterone-supplemented pregnant mouse model. Administration of letrozole, a specific aromatase inhibitor, to these mice blocked the stromal differentiation process. Gene expression profiling ...
