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2009 OCT 19 ... The presentation demonstrated that blue-fluorescent small molecule compounds, such as camptothecin, strongly interfere with nuclear condensation measurement based upon Hoechst dye but do ...
2009 NOV 9 ... exhibited cytotoxic activity. Because structurally related antitumor alkaloids such as camptothecin and fagaronine are known to function as intercalative topoisomerase poisons, it is ...
2009 NOV 23 ... research published in the journal Molecular Pharmaceutics, "Polymer conjugates of camptothecin (CPT) have been pursued as a solution to the difficulties present in treating cancers ...
2009 OCT 12 ... Apo2L/TRAIL alone and in combination with cisplatin and the topoisomerase I inhibitor camptothecin for different periods. Metabolic activity of the tissue was measured by alamar blue. ...
2009 NOV 23 ... Challenges for Development. The review article, entitled, "XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer," was authored by ...
2009 NOV 9 ... drugs, cisplatin (Platinol ™) and 5-fluorouracil, to the DNA damaging drug, camptothecin, and to UV-C irradiation. The sensitization effects of Spd-CoA are not observed in ...
2009 NOV 23 ... "Other chemotherapeutic inducers of apoptosis such as etoposide and camptothecin also led to a robust induction of Hsp70 surface expression. Hsp70 expression was, ...
2009 NOV 3 ... degradation are associated with cancer cell resistance to the chemotherapeutic agent, camptothecin," wrote Y.W. Zhang and colleagues, Case Western Reserve University. The ...
2009 NOV 24 ... requirement for cells to cope with this insult is the same as for cells treated with camptothecin, which traps topoisomerase I-DNA cleavage complexes genome-wide. hence, a single ...
2009 SEP 28 ... According to recent research from the United States, "Camptothecin (CPT) has potent broad-spectrum antitumor activity by inhibiting type I DNA ...
2009 OCT 6 ... as OjSTR, GenBank Accession No. 1087598), which catalyzes a committed step in camptothecin biosynthetic pathway, was isolated from young leaves of Ophiorrhiza japonica for the ...
2009 NOV 23 ... a wide-range of hematologic and solid tumor cells. More excitingly, our studies of 5q in camptothecin (CCRF-CEM/C2) and mitoxantrone (HL-60/MX2) resistant cancer cells highlight its ability ...
2009 OCT 5 ... pathway. It is striking that hypoxia-inducible factor 1 alpha (HIF-1 alpha) inhibitor, camptothecin, suppressed hypoxia-induced COX-2 expression rather than pyrrolidine dithiocarbamate, a ...
2009 NOV 16 ... "In this study, several designs were used to investigate the resistance mechanism to camptothecin and etoposide in hepatocellular carcinoma Hep3B cells. Tunicamycin significantly ...
2009 NOV 9 ... "A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin using scaffold modification strategy. Thirty-one new compounds were synthesized and ...
2009 OCT 19 ... subunit (PP2A/C) enhances Ku and DNA-PK activities with accelerated DSB repair. Camptothecin-induced DSBs promote PP2A to associate with Ku 70 and Ku 86. PP2A directly ...
2009 NOV 23 ... of drug loading (as demonstrated for a fourth tested compound, anticancer drug camptothecin)," wrote A.D. Costache and colleagues, Rutgers University. The researchers ...
2009 OCT 5 ... "A recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with efficacy and risk of ...
