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2009 DEC 2 -- "T-cell receptor (TCR) genomic loci undergo somatic V(D)J recombination, plus the addition/subtraction of nontemplated bases at recombination junctions, in order to generate the repertoire of structurally diverse T cells necessary for antigen......
2009 DEC 2 -- "Crosslinking of IgE-bound Fc epsilon R1 triggers mast cell degranulation. Previous fluorescence recovery after photobleaching (FRAP) and phosphorescent anisotropy studies suggested that Fc epsilon R1 must immobilize to signal," scientists in......
2009 DEC 2 -- Current study results from the report, 'Mouse oviduct-specific glycoprotein is an egg-associated ZP3-independent sperm-adhesion ligand,' have been published. "Mouse sperm-egg binding requires a multiplicity of receptor-ligand interactions,......
2009 DEC 2 -- "Migration of CD4(+)CD25(-)FOXP3(+) regulatory T cells (Treg) is important for suppressing immune responses in different tissues. Previous studies show that the majority of Treg at birth express gut homing receptor alpha(4)beta(7) and that only......
2009 DEC 3 -- "Primary ovarian insufficiency, also known as premature ovarian failure, is characterized by loss of function of the ovaries before the age 40. Observational evidence of familial associations suggests a genetic basis for ovarian insufficiency,"......
2009 DEC 2 -- "CX(3)CR1(+) and CD103(+) dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear,"......
2009 DEC 2 -- "T cell receptor (TCR) and B cell receptors (BCR) junctions, also known as the CDR3, are where the V, D, and J gene segments converge, coding for a loop structure important for contacting ligands. J segments contribute to the formation of the......
2009 DEC 2 -- "Several tools have proved useful in the study of invariant natural killer T (iNKT) cells, including CD1d-deficient mice, J alpha 281-deficient mice, synthetic lipid antigens and antigen-loaded CD1d tetramers. However, the generation and......
2009 DEC 2 -- According to a study from Erlangen, Germany, "Glaucoma, a main cause of blindness in the developed world, is characterized by progressive degeneration of retinal ganglion cells (RGCs), resulting in irreversible loss of vision. Although members......
2009 DEC 2 -- According to recent research from the United States, "The lineage fate of developing thymocytes is determined by the persistence or cessation of T cell receptor (TCR) signaling during positive selection, with persistent TCR signaling required......
2009 DEC 1 -- According to recent research from the United States, "TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-kappa B canonical signaling directly in osteoclast precursors (OCPs) to......
2009 DEC 1 -- "Bone undergoes a continuous cycle of renewal, and osteoclasts - the cells responsible for bone resorption - play a pivotal role in bone homeostasis. This resorption is largely mediated by inflammatory cytokines such as TNF-alpha," scientists......
2009 DEC 1 -- "Surface-exposed loop residues, Pro389 (beta(6)-beta(7) loop), Glu417 (beta(8)-beta(9) loop), Tyr455 and Asn456 (beta(10)-beta(11) loop), in the receptor-binding domain of the Bacillus thuringiensis Cry4Ba toxin have been previously demonstrated......
2009 DEC 1 -- "Minor group human rhinoviruses (HRVs) bind three members of the low-density lipoprotein receptor (LDLR) family: LDLR proper, very-LDLR (VLDLR) and LDLR-related protein (LRP). Whereas ICAM-1, the receptor of major group HRVs actively contributes......
2009 DEC 1 -- According to recent research from the United States, "Chemoreceptors are key components of the high-performance signal transduction system that controls bacterial chemotaxis. Chemoreceptors are typically localized in a cluster at the cell pole,......
2009 DEC 1 -- According to recent research published in the Journal of Dental Research, "During orthodontic tooth movement, there is local production of chemokines and an influx of leukocytes into the periodontium. CCL5 plays an important role in osteoclast......
2009 DEC 1 -- According to a study from the United States, "The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition was investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and......
2009 DEC 2 -- "A higher frequency of skewed X chromosome inactivation (XCI) is found in patients with autoimmune thyroid disease (AITD) than in controls. Although goitre is often present in AITD, a recent study failed to show an association between XCI and......
2009 DEC 1 -- "Fibroblast growth factor (FGF) receptor substrate 2 alpha (FRS2 alpha) is the main mediator of signaling in the FGF pathway. Recent studies have shown that mitogen-activated protein kinase ( MAPK) phosphorylates serine and threonine residues in......
2009 DEC 2 -- According to recent research from Okinawa, Japan, "Shovel shape of upper incisors is a common characteristic in Asian and Native American populations but is rare or absent in African and European populations. Like other common dental traits,......
