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2009 NOV 27 ... "In the structures of the HDV ribozyme a cytosine nucleobase resides at the active site poised to participate directly in catalysis ...
2009 NOV 9 ... favorable pi-pi interactions between either skimmianine or stauranthine and the guanine-cytosine base pair. Furthermore, the lowest-energy face-to-face orientation of stauranthine with ...
2009 NOV 9 ... system to prevent GO-associated mutations, presumably through preferential insertion of cytosine opposite replication-blocking GO lesions. Furthermore, the Pol eta-dependent bypass of ...
2009 NOV 23 ... of myotonic dystrophy type 1 (DM1) is based on the identification and determination of a cytosine-thymine-guanine (CTG) repeat expansion in the DMPK gene. This is usually done by ...
2009 NOV 2 ... "In this study, the expression levels, imprinting status, and the extent of cytosine methylation of the IGF2 gene was evaluated in 20 of 24 cases of osteosarcoma using ...
2009 NOV 16 ... in the tolerance of O-6-chloroethylguanine or the subsequently formed N1-guanine-N3-cytosine interstrand cross-link is shown. Rev3L had no influence on base excision repair (BER) of ...
2009 NOV 23 ... deletions and mutations, growth regulatory genes can be inactivated via methylation of cytosine-residues in their promoter regions. Hypermethylation of promoter CpG islands is now ...
2009 NOV 2 ... skeletal muscle from normal glucose-tolerant and type 2 diabetic subjects, we identified cytosine hypermethylation of peroxisome proliferator-activated receptor gamma (PPAR gamma) ...
2009 NOV 1 ... (8-oxoGua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine when paired with cytosine in oxidatively damaged DNA. Excision of 8-oxoGua mispaired with adenine may lead to G ...
2009 OCT 27 ... approximately seven-fold higher than the reverse transition in intron regions due to cytosine deamination, but the effect is strongly reduced in mRNA regions and almost entirely lost ...
2009 NOV 2 ... carcinomas exhibited microsatellite instability at the MALT1 locus and a specific cytosine methylation positioned at -256 from the gene, and the expression was recovered by ...
2009 NOV 23 ... mutagenic threat to all organisms, particularly those living in extreme habitats. Cytosine is readily deaminated to uracil, which base pairs with adenine during replication, and ...
2009 NOV 2 ... series. In the pyrimidine series, 1-(4-C-methyl-2-fluoro-beta-D-arabinofuranosyl) cytosine (13) was found to be highly cytotoxic and had significant antitumor activity in mice ...
2009 NOV 23 ... found in the peripheral blood and on bone marrow aspiration smears. Chemotherapy with cytosine arabinoside and idarubicin was ineffective and the patient died of multi-organ failure ...
2009 NOV 9 ... is newly published data in Hematology. "To assess the outcomes of outpatient high dose cytosine arabinoside consolidation cycles in pediatric acute myeloid leukemia (AML) patients in ...
2009 NOV 17 ... sites occur on the Watson-Crick edge of guanine and the Hoogsteen edge of cytosine. We modified the 'Find RNA 3D' (FR3D) software suite to automatically find and ...
2009 NOV 16 ... investigators in the United States report. "After treatment with cytosine arabinoside (araC), enzymatically inactive GAPDH accumulated in the nucleus. Experiments ...
2009 OCT 26 ... breaks (DSBs). DNA deaminases act on regions of single-stranded DNA and deaminate cytosine to uracil (dU)." "In the immunoglobulin locus, this lesion will initiate ...
2009 NOV 3 ... the journal Molecular Biology and Evolution, "Given the dramatic variation in guanine-cytosine (GC) content observed in prokaryotes, from similar to 20% to similar to 75% GC, one ...
