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2009 NOV 23 ... for many patients' deaths." CEL-SCI's L.E.A.P.S.™ (Ligand Epitope Antigen Presentation System) technology allows the Company to direct an immune response ...
2009 NOV 23 ... recombinant L. monocytogenes (Lm)-infected antigen-presenting cells can prime and expand epitope-specific CD8(+) T cells in vitro and such CD8(+) T cells recognize not only ...
2009 NOV 23 ... of Foxp3(+) T-regulatory cells. Furthermore, we have characterized the immunodominant epitope involved in this effect (NAPYLPSCL) and demonstrated that coinjection of NAPYLPSCL with ...
2009 NOV 23 ... pathogens. Bone marrow-derived DC (BM-DC) pulsed with a single immunodominant CTL epitope, listeriolysin O (LLO) 91-99, of Listeria monocytogenes (LM) were intratracheally ...
2009 NOV 23 ... and protection from lethal MARV challenge in BALB/c mice. We discovered a CD8+ T-cell epitope within both the MARV glycoprotein (GP) and nucleoprotein (NP) that triggered cytotoxic ...
2009 NOV 27 ... "CD8(+) T-cells specific for MART-1-(26-35), a dominant melanoma epitope restricted by human leukocyte antigen (HLA)A* 0201, are exceptionally common in the ...
2009 NOV 17 ... with preexisting immunity to Ad5. The rAd5 immunization induced lower-frequency Gag epitope-specific CD8(+) T cells in the colonic mucosa than in the peripheral blood. There was ...
2009 NOV 24 ... of Nephrology. The researchers concluded: "Inter-and intra-molecular epitope spreading can occur during the development of human anti-GBM disease." ...
2009 NOV 23 ... or antinuclear antibodies. Similarly, the presence or absence of the HLA-DRB1 shared epitope or the RA-associated PTPN22 allele had no influence on this association," wrote M. ...
2009 NOV 23 ... component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell epitope,' are detailed in a study published in Scandinavian Journal of Immunology. "Heat shock ...
2009 NOV 23 ... mAbs. This study assessed the optimal dose, route, schedule, and the targeted CD22 epitope. Raji NHL-bearing nude mice were studied. A non-blocking anti-CD22 mAb (HB22.27) was ...
2009 NOV 23 ... Japan report. "In this study, we coupled liposomes to immunodominant CTL epitope peptides derived from lymphocytic choriomeningitis virus (LCMV) and evaluated its ...
2009 NOV 23 ... of Iowa. The researchers concluded: "Peripheral injection of the epitope-modified AAVs expressing the enzymes lacking in LSD mice reconstituted enzyme activity ...
2009 NOV 23 ... together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope," scientists writing in the Journal of Immunotherapy report. "Persistence ...
2009 NOV 23 ... transgenic mice. Ran1 1Y was superior to other APLs and wild-type peptides in eliciting epitope-specific CTL immune responses both in vitro and in vivo. In summary, a wild-type...
2009 NOV 24 ... have been found in organisms belonging to Protostomia, this unit might be a common glyco-epitope recognized by galectins in these organisms." Takeuchi and colleagues ...
2009 NOV 16 ... class I major histocompatibility complex (MHC)/peptide complexes at the cell surface. An epitope-linked beta 2-microglobulin (beta 2m) molecule could provide a simple and more efficient ...
2009 NOV 16 ... of the virus proteins on their surface, offering a "molecular fingerprint" called an epitope for killer T-cells from the immune system to identify. This triggers an immune response, ...