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2009 SEP 14 ... disorders (MPDs). This group of diseases includes myelofibrosis, polycythemia vera and essential thrombocythemia. In addition, Cytopia has identified potential activity of CYT387 in a range of cancers ...
2009 AUG 3 ... with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF). The SPA provides agreement that the study design and planned ...
2009 AUG 10 ... Inhibitor Program INCB18424: (oral formulation) Myelofibrosis, Polycythemia Vera and Essential Thrombocythemia Agreement reached with the U.S. Food and Drug Administration (FDA) for a ...
2009 NOV 16 ... Inhibitor Program INCB18424: (oral formulation) Myelofibrosis, Polycythemia Vera and Essential Thrombocythemia Continued patient enrollment of the Phase III registration trials, ...
2009 AUG 31 ... The aim of this study, which included 353 patients with polycythemia vera and 467 with essential thrombocythemia, was to assess whether the risk of developing LPN is increased in MPN patients." ...
2009 AUG 31 ... available. "The screening for JAK2 V617F mutation in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis offers crucial information for the final diagnosis of ...
2009 SEP 7 ... has been recently identified as an independent predictor of major thrombosis in both essential thrombocythemia (ET) and polycythemia vera (PV). However, whether leukocytosis should be simply ...
2009 NOV 9 ... the classic myeloproliferative disorders (MPDs), which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Nonetheless, genetic defects have not yet been ...
2009 JUL 20 ... those with primary MF or those whose MF has evolved from antecedent polycythemia vera or essential thrombocythemia, presents many challenges to the hematologist. MF patients have a range of debilitating ...
2009 AUG 31 ... therapy, we analyzed the clinical course of 187 patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) followed at two Italian Institutions over a period of 7 years," investigators in ...
2009 AUG 10 ... neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 idiopathic myelofibroses," scientists in Dijon, France report. "No ...
2009 NOV 23 ... domain (TMD) of c-MPL, which encodes the thrombopoietin receptor, caused familial essential thrombocythemia. Here, we show that the Asn505 mutation induces both autonomous dimerization of c-Mpl ...
2009 JUL 6 ... Fresh data on life sciences are presented in the report 'Cytogenetic abnormalities in essential thrombocythemia: prevalence and prognostic significance.' "In the current study we describe ...
2009 OCT 12 ... (10 of 12) in patients with primary myelofibrosis or patients with polycythemia vera or essential thrombocythemia who secondarily evolved toward myelofibrosis or acute myeloid leukemia. (Blood. 2009; ...
2009 AUG 31 ... diseases, we hypothesized a role for microparticles in the pathogenesis of thrombosis in essential thrombocythemia," scientists in Netherlands report. "In plasma samples from 21 patients ...
2009 NOV 2 ... currently approved specific therapies for myelofibrosis (MF), polycythemia vera (PV), or essential thrombocythemia (ET), which collectively constitute the major myloproliferative diseases. These ...
