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2009 NOV 16 ... Cancer Index®, which refines and improves risk stratification in patients with estrogenreceptor (ER)-positive, lymph-node negative breast cancer. More information is available ...
2009 NOV 29 ... cancer each year. Half of them will not survive.The drugs, which keep estrogen from working in cells, also cleared precancerous growths, or lesions, in both the cervix ... zeroed in on one of the two receptors that mediate estrogen function in cells - estrogen receptor (ER) alpha. He crossed his HPV mice with mice in which ER alpha had been knocked out, ... from pre-existing infections."Virtually all cervical cancers in women test positive for HPV 16," says Lambert, a professor of oncology at the UW-Madison School of Medicine ...
2009 NOV 23 ... breast cancer." "Here, we investigated effects of alpha-ESA on both estrogenreceptor (ER)-negative MDA-MB-231 (MDA-wt) and ER-positive MDA-ER alpha 7 human breast ...
2009 NOV 23 ... 0.52; 95% confidence interval, 0.32-0.85). Risk estimates were similar in women with an estrogenreceptor-positive and estrogenreceptor-negative breast cancer. Use of vitamin D ...
2009 NOV 23 ... interval (CI): 1.03, 1.38; p=0.007 for linear trend), especially when tumors were estrogenreceptor-positive/progesterone receptor-positive. The 'healthy/Mediterranean' pattern ...
2009 NOV 16 ... cancer and are the treatment of choice in postmenopausal women who have tumors that are estrogen receptor positive. The depletion of estrogen seen with AI therapy is significant and translates to ...
2009 NOV 9 ... defects which may result from a skewing of the progenitor population to favor estrogen receptor positive cells (ER alpha). This is of considerable interest as ER alpha cells are non-cycling in ...
2009 NOV 23 ... were not compared in human tissues. This study focused oil assessment of expression of estrogenreceptor alpha (ER alpha) and PRs in relation to the expression of Cx26 and Cx43 in 88 ... and analysis of these proteins' expression in comparison with anatomoclinical features. Positive ER(x and PR nuclear staining was present in 66 (75%) and 60 (68.2%) of all studied ...
2009 NOV 23 ... including tumor size, histological grade, lymph node status, expression of estrogenreceptor (ER), expression of progesterone receptor (PR), expression of c-erbB2, ... tumor margins correlated significantly with lower histological grade (I-II) and positive PR expression. Rim enhancement was significantly correlated with high histological ...
2009 NOV 2 ... accounting for its influence on risk. Whether physical activity has greater influence on estrogenreceptor-or progesterone receptor-negative breast cancers or affects receptor-negative ... progesterone receptor-negative breast cancers or affects receptor-negative and receptor-positive tumors equally remains a question. Studies have established that lower sex hormone ...
2009 NOV 16 ... notoriously difficult to treat because the patients' tumors lack the receptors for the estrogen and progesterone hormones, as well as the HER2 protein-all of which are treated by ... for the one in five women who have HER2 positive factor (Human Epidermal growth factor Receptor 2), there is a host of new drugs that go beyond Herceptin for treating breast cancer. ...
2009 NOV 23 ... virus (HPV)." "We also determined whether DHEA effects are mediated by estrogen and androgen receptors. Proliferation of C33A (HPV-negative), CASKI (HPV16-positive) and ... of cervical cancer cells, but its effect is not mediated by androgen or estrogen receptor pathways," wrote R.A. Giron and colleagues. The researchers concluded: ...
2009 NOV 9 ... patients with HER2-positive tumors (76% v 31% for HER2-negative tumors; P = .003), with estrogenreceptor (ER)-negative tumors (75% v 27% for ER-positive tumors; P = .001), or with ...
2009 NOV 10 ... "Following estrogenic activation, the estrogenreceptor-alpha (ER alpha) directly regulates the transcription of target genes via DNA ... confirmed by demonstrating that pre-miR-18a was significantly upregulated in ER alpha-positive compared to ER alpha-negative breast cancers. Mechanistically, miRNAs derived from these ...
2009 NOV 23 ... the growth of established human breast tumors in athymic mice with low circulating estrogen concentrations, In this study, we determined the effect of FS compared with pure lignan ... an implanted 17 beta-estradiol (E2) pellet (0.36 mg), were injected with human estrogen receptor (ER) positive breast cancer cells (MCF-7)." "When tumors were ...
2009 NOV 23 ... According to recent research from the United States, "Mice lacking estrogenreceptor alpha in the pituitary gonadotroph (PitEsr1KO) were generated to determine the ... role in estrogen negative feedback. PitEsr1KO mice also demonstrate a defect in estrogen positive feedback, as surge LH values and estrous cyclicity are absent in these mice," wrote ...
2009 NOV 23 ... Research findings, 'In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to ... arising in postmenopausal women are estrogen dependent or positive for estrogen receptor (ER) in carcinoma cells despite markedly low plasma or circulating estrogen ...
2009 NOV 23 ... "Traditional prognostic markers for breast cancer include estrogenreceptor (ER), progesterone receptor (ER) and HER2/neu. Negative staining for these ... distal recurrence in the basal-like and normal-like subgroups with that of women with ER-positive breast cancer. Only 16 of 958 women had normal-like breast cancers. These cancers ...
