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2009 NOV 1 ... anti-HIV-1 therapeutics," scientists in the United States report. "Flavopiridol, a small molecule CDK inhibitor, blocks HIV-1 Tat transactivation and viral replication ...
2009 MAY 4 ... results of a phase 1 trial in patients with chronic lymphocytic leukemia (CLL) whereby flavopiridol was administered intravenously as a 30-minute bolus followed by 4-hour infusion. We now ...
2009 NOV 9 ... lumiliximab, thalidomide and its analog lenalidomide, the semi-synthetic flavonoid flavopiridol and other agents which are currently undergoing clinical trials with promising ...
2009 AUG 17 ... resulted in a transcriptional down-regulation of Mcl-1, a key molecule associated with flavopiridol-induced apoptosis, thereby leading to susceptibility to therapeutic intervention with ...
2009 JUN 22 ... Mdr1a/1b(-/-), (-/-), Bcrp(-/-), and Mdr1a/1b(-/-), (-/-) Bcrp(-/-) mice. Four drugs, flavopiridol, imatinib mesylate (Gleevec), PF-407288, and prazosin, with different transport ...
2009 AUG 31 ... have been developed and are being actively investigated in AML. Among these agents is flavopiridol, which interferes with key steps of the cell cycle and effectively promotes cell death, ...
2009 APR 20 ... treatment (alemtuzumab), immuno-modulating drugs (lenalidomide), CDK inhibitors (flavopiridol) and steroids."
Zenz and colleagues published their study in Leukemia ...
2009 JAN 5 ... and glial scarring," scientists in the United States report.
"Flavopiridol-a cyclin-dependent kinase (CDK) inhibitor that is neither specific nor selective-is ...
2009 JUN 29 ... Research findings, 'A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer,' ...
2009 JUN 29 ... from DNA replication. Thus, CPT modulates P-TEFb equilibrium in a manner similar to Flavopiridol (FP), a pan-Cdk inhibitor proposed as chemotherapeutic agents against cancers. We ...
2009 JUN 29 ... the result of transcriptional inhibition rather than cleavage by caspase. Compared with flavopiridol and roscovitine, SNS-032 was more potent, both in inhibition of RNA synthesis and at ...
2009 APR 20 ... MET transcript and protein levels and this will lead to cell death. Pharmacological (flavopiridol) and molecular (shRNA) transcription inhibitor were used to impede formation of MET ...
2009 MAR 2 ... either wild-type or mutated ABCG2 to the ABCG2 substrate anti-cancer drugs flavopiridol and mitoxantrone. Neither AG1478 nor erlotinib sensitized ABCG2-overexpressing cells to ...
2009 JUL 13 ... of the IE2 protein at these sites. Infection in the presence of the cdk9 inhibitors Flavopiridol and DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) allowed cdk9 localization to ...
2009 AUG 31 ... cells. In this study, we investigated the effect of the cdk inhibitor flavopiridol in anaplastic large cell lymphomas, in which unrestrained proliferation depends on ...
2009 SEP 21 ... interaction fields and also by a docking study of the known inhibitors kenpaullone and flavopiridol." Kruggel and colleagues published their study in QSAR & Combinatorial ...
2009 NOV 9 ... apoptosis in CLL cells independent of p53 mutational status. The synthetic flavone flavopiridol demonstrated promising in vitro activity in CLL. In initial phase I studies using a ...
2009 APR 13 ... that control cell cycle progression, i.e., functional retinoblastoma protein (pRb). Flavopiridol inhibits proliferation and induces apoptosis in SCLC cell lines."
...
2008 DEC 29 ... cells and downregulated during the apoptosis induced by other plant-derived molecules (flavopiridol, polyphenols, or hyperforin). This suggests different mechanisms of action for the ...
