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2009 NOV 23 ... on the development and commercialization of FOLOTYN™ (pralatrexate injection), a folate analogue metabolic inhibitor. FOLOTYN is the first and only drug approved in the U.S. ...
2009 NOV 23 ... "Aberrant DNA methylation is a recognized feature of human cancers, and folate is directly involved in DNA methylation via one-carbon metabolism. Previous reports also ...
2009 NOV 23 ... available," says Rampersaud. "Fresh citrus supplies key nutrients such as vitamin C, folate, potassium and fiber to help support overall good health when included as part of a ...
2009 NOV 23 ... were significantly higher in Native Africans than in both American groups. Colonic folate and biotin content, measured by Lactobacillus rhamnoses and Lactobacillus plantarum ATCC ...
2009 NOV 23 ... worldwide. Methylene tetrahydrofolate reductase (MTHFR) plays an important role for folate metabolism and is also an important source for DNA methylation and DNA synthesis ...
2009 NOV 23 ... risk (odds ratio [OR] = 1.63; 95% CI 1.21-2.22) compared with lowest intake group. Folate consumption modified the ethanol effect (p-interaction = 0.03). Current smokers had a ...
2009 NOV 23 ... is expected to retain the antitumor activity of paclitaxel and specifically target folate receptor (FR)-expressing tumors, thereby increasing the bioavailability and efficacy of ...
2009 NOV 23 ... influenced risk for colorectal adenoma recurrence among 979 participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or aspirin and followed for ...
2009 NOV 25 ... in the journal Molecular Pharmaceutics, "Herein we report on the potencies of 4 related folate-conjugated tubulysins constructed with either tubulysin B hydrazide (EC0305), tubulysin ...
2009 NOV 23 ... to test the hypothesis that low plasma vitamin B-12 concentrations combined with high folate concentrations in pregnancy are associated with a higher incidence of gestational ...
2009 NOV 16 ... and 62% had energy intake deficits. Micronutrient intake was low for calcium, magnesium, folate, zinc (for men) and dietary fibre. Vitamin D deficiency (serum 25OH Vitamin D< ...
2009 NOV 23 ... According to a study from the United States, "Folate and other methyl-group nutrients may play a key role in pancreatic carcinogenesis ...
2009 NOV 16 ... reductase as human cell lines, yet the sensitivity to methotrexate (ED50), the folate antagonist that targets this enzyme, is similar. Our previous studies showed that ...
2009 NOV 23 ... mol %))(MW:5K)-b-PEG(MW:2K) and poly(L-lactic acid)(MW:3K)-b-PEG(MW:2K)-folate (80/20 wt/wt %) was previously optimized by physicochemical and in vitro tests for both ...
2009 NOV 16 ... He says their study found no evidence to link asthma with dietary folate, which is found in green, leafy vegetables, certain fruits and nuts. Nearly ...
2009 NOV 23 ... subunit-ERK2 interactions but only slightly altered MAPK activation in response to folate. Expression of the Galpha4 subunit with the altered D-motif in galpha4(-)cells allowed ...
