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2009 NOV 27 ... synthesis of phosphatidylethanolamine (PtdEtn). Hepatocyte-specific deletion of the ECT gene in mice resulted in normal appearing animals without overt signs of liver injury or ... Triacylglycerol accumulation was associated with a significant elevation in the expression of the transcription factors and target genes that drive de novo lipogenesis," wrote R. ...
2009 NOV 27 ... "The transcription dynamics of subunit A of the key gene in methanogenesis (methyl coenzyme M reductase; mcrA) was studied to evaluate the ... ratio increase was only 18-fold. mcrA transcript dynamics suggested steady-state expression in peat soil after incubation for 24 and 48 h, similar to that in stationary-phase ...
2009 NOV 27 ... Zap1-responsive manner. As a result, we have identified a new mechanism of Zap1-mediated gene repression whereby transcription of the MET3, MET14, and MET16 genes is repressed in ... a component of the SCFMet30 ubiquitin ligase, is a direct Zap1 target gene. MET30 expression is increased in zinc-limited cells, and this leads to degradation of Met4, a ...
2009 NOV 27 ... injury mechanisms are not fully understood. We examined freeze-thaw injury by indirect gene expression analysis during postthaw incubation after freeze-thaw treatment using DNA microarray ...
2009 NOV 27 ... factor with significant potential in treatment of Parkinson's disease. Combining gene targeting of animal somatic cells with nuclear transfer technique has provided a ... tumor cell line Bcap-37 is valid for bioactivity analysis of mammary gland specific expression vector."Zhang and colleagues published their study in Applied Biochemistry ...
2009 NOV 29 ... communis L.) 'La France' and 'Ballade' with the Citrus FLOWERING LOCUS T (CiFT) gene, which induces early flowering. Subsequent DNA blot analysis of the transformed and ... however, the results of RNA gel blot analysis indicated a strong correlation between the expression of the CiFT gene and floral bud differentiation ill vitro. Flowers that developed ill ...
2009 NOV 27 ... criteria. The genes identified here likely reflect the existence of distinct programs of gene expression governing the development, maturation, and function of the newly identified ...
2009 NOV 27 ... proteins.""Here we show that ultraviolet radiation and heat shock protein gene expression explain a significant amount of the variation in hyper-melanization-the phenotypic ...
2009 NOV 27 ... into lipid rafts leading to the activation of downstream signaling pathways and target gene expression. However, docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, inhibited LPS- ...
2009 NOV 27 ... have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kB activation."Shin and ...
2009 NOV 27 ... both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin-and PC6-selective inhibitor alpha(1)-PDX. By ... the hypothesis that tissue-specific cleavage of pro-BMP4 is regulated by differential expression of a site-specific protease, we identified the PCs that cleave each site in vivo. In ...
2009 NOV 27 ... as an oncologist, Bradner became deeply interested in a human protein called NOTCH. The gene encoding this protein is often damaged, or mutated, in patients with a form of blood ... by NOTCH. Interestingly, these effects are also seen at the level of gene activity or "expression." The researchers looked at the expression levels of genes across the genome, in both ...
2009 NOV 27 ... inhibits transcriptional activity of HNF4 alpha and modulates hepatic gluconeogenic gene expression. Hepatic DAX-1 expression is increased by insulin and SIK1 (salt-inducible kinase 1), ...
2009 NOV 26 ... of Medicinal Food (Regular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Diet. Journal of ... weight, retroperitoneal interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression, and plasma IL-6 and TNF-alpha. Tart cherry diet also increased retroperitoneal fat ...
2009 NOV 27 ... "A new method without any special devices for direct transformation of linear gene cassettes was developed. Its feasibility was verified through 5'-fluorescent dye ... dye (fluorescein isothiocyanate, FITC)-labeled fluorescent tracing and transient expression of a gus reporter gene," scientists in People's Republic of China ...
2009 NOV 27 ... of transcription. This was best exemplified in the regulation of the E-cadherin gene. Indeed, we uncovered a regulatory cascade whereby p110 CUX1 binds to the snail and slug ... with functions related to cell motility, and we then identified those targets whose expression was directly regulated by CUX1 in a cell line whose migratory potential was strongly ...
2009 NOV 27 ... regulation system mediated by the tetracycline repressor (TetR) is widely used to study gene expression in prokaryotes and eukaryotes. To study multiple genes in parallel, a triple mutant ...
2009 NOV 27 ... screen, we identified the miR-192/194 cluster as a potent inhibitor of the entire Period gene family. In accordance, the exogenous expression of miR-192/194 leads to an altered ...
2009 NOV 29 ... in the petals of ray florets is caused by the loss of a carotenoid cleavage dioxygenase gene, CmCCD4a. Here we introduced two separate CmCCD4a RNAi constructs into 'Jimba' by ... transformation. The double-transformation effectively suppressed CmCCD4a expression in petals, which became yellow. The yellowest transformants contained 102 mu g.g(-1) FW ...
2009 NOV 29 ... Yerkes National Primate Research Center.The scientists focused on gene expression - the process by which a gene's DNA sequence is converted into cellular ...
