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2009 NOV 2 ... Our results indicate a role for CD44 in modulation of susceptibility to acetaminophen hepatotoxicity," wrote A.H. Harrill and colleagues, University of North Carolina. The ...
2009 NOV 23 ... US hospitals with the 72-hour oral protocol from 1976 to 1985. The primary outcome was hepatotoxicity (aminotransferase levels >1,000 IU/L). Of the 4,048 patients analyzed, 2,086 were in ...
2009 NOV 9 ... such as nausea or vomiting are uncommon. There are occasional case reports of severe hepatotoxicity. Surveillance and reporting of adverse events will need to be improved when recommended ...
2009 NOV 16 ... that the adverse drug event was probable. This case report represents a very rare severe hepatotoxicity due to atenolol and illustrates the diagnostic difficulties raised by such clinical ...
2009 NOV 2 ... particle with polyethylene glycol (PEG) could reduce transduction of hepatocytes and hepatotoxicity after systemic (intravenous) administration of oncolytic adenovirus serotype 5 (Ad5)." ...
2009 NOV 10 ... was determined to be 3.48 mu g/kg/day, which is far below the lowest dose to cause hepatotoxicity (15 mu g/kg/day) suggested by the International Program on Chemical Safety. No ...
2009 NOV 16 ... drug ( NSAID) that has been associated with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. In previous studies, cotreatment of rats with SLD ...
2009 NOV 2 ... responses in cases of human exposure. However, no pathways and processes related to hepatotoxicity in rats were observed in human hepatocytes. Still, repression of energy-consuming ...
2009 NOV 2 ... a study from Oslo, Norway, "The clinical use of immunotoxins (ITs) has been hampered by hepatotoxicity, and the induction of a strong human-anti-IT response. The human-anti-IT response ...
2009 NOV 16 ... patients. The research collaboration will initially focus on three drug-induced SAEs: hepatotoxicity, serious skin rashes, and extreme weight gain in users of atypical antipsychotic ...
2009 NOV 2 ... of heat shock protein 90 inhibitors, geldanamycin and 17-AAG, were limited by hepatotoxicity and the need for solvent carrying agents. In contrast, retaspimycin, or IPI-504, a ...
2009 NOV 23 ... prophylaxis. However, its clinical use is limited by two life-threatening side effects: hepatotoxicity and teratogenicity," scientists writing in the journal Birth Defects Research Part B, ...
2009 NOV 16 ... development of computational models which can be used to improve the predictability of hepatotoxicity and the safety profiling of compounds in liver cells. Under the terms of ...
2009 NOV 9 ... disease. Among the 27 herbs reported to be ingested, 10 are associated with bleeding and hepatotoxicity, as described in the literature," wrote C. Schieman and colleagues, University of ...
2009 NOV 1 ... discussions have emerged as to whether its use may be associated with the risk of rare hepatotoxicity in a few susceptible women," researchers in Hanau, Germany report. "We ...
2009 NOV 26 ... the results indicated a significant protection by these extracts against ethanol-induced hepatotoxicity (P < .05). Again the groups that were treated with extracts only (EX2 and EX4) showed ...
2009 NOV 10 ... concluded: "This study suggests that embelin acts as a natural antioxidant against hepatotoxicity induced in rats." Singh and colleagues published their study in Basic & ...
2009 NOV 9 ... of rigorous models of hepatic metabolism for preclinical screening of drug clearance and hepatotoxicity," scientists in the United States report. "Here, we present a ...
