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2009 NOV 29 ... organs are so responsive to estrogen, our lab and others began to focus on that hormone," Lambert says.Sang-Hyuk Chung, a postdoctoral fellow in Lambert's lab, ... zeroed in on one of the two receptors that mediate estrogen function in cells - estrogen receptor (ER) alpha. He crossed his HPV mice with mice in which ER alpha had been knocked out, ...
2009 NOV 24 ... Cellular Biology report. "FoxA1 has a dominant effect in the absence of hormone and induces a cluster of DNase I-hypersensitive sites in the segment comprising bp -400 ... "Reconstitution of the glucocorticoid receptor (GR)-regulated mouse mammary tumor virus (MMTV) promoter in Xenopus oocytes was used to ...
2009 NOV 25 ... dihydrotestosterone. It is therefore of interest as a potential new therapeutic agent in hormone-dependent conditions and is under development as a nutraceutical," scientists writing ... "The soy isoflavone metabolite, S-(-)equol, has selective affinity for estrogen receptor (ER),G and also antagonizes in vivo the action of dihydrotestosterone. It is therefore ...
2009 NOV 23 ... detailed in 'Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk' have been presented. "The relevance of ...
2009 NOV 23 ... a 13-h blood sampling protocol for determination of LH pulse characteristics and various hormone concentrations. Oral P was then discontinued, and oral mifepristone (50, 100, or 200 mg ... "We explored this notion in a similar experimental paradigm by administering a P-receptor antagonist (mifepristone) after P withdrawal while continuing E-2. Studies were ...
2009 NOV 23 ... polypeptide 1 (ADCYAP1) affected gonadotrophs. In static culture, gonadotropin-releasing hormone (GnRH) stimulated transcription of all the gonadotropin subunits." "In ... (4.7-fold +/- 0.57-fold) than did low-frequency pulse (2.72-fold +/- 1.09-fold). ADCYAP1 receptor gene (Adcyap1r) expression was increased significantly following pulsatile GnRH ...
2009 NOV 27 ... additional information, contact H.S. Choi, Chonnam National University, Hormone Research Center, School Biology Science & Technology, Kwangju 500757, South ... congenital critical region on X chromosome, gene 1) is an atypical member of the nuclear receptor family and acts as a corepressor of a number of nuclear receptors. HNF4 alpha ...
2009 NOV 23 ... female mice are subfertile or infertile and have elevated levels of serum luteinizing hormone (LH) and LH beta subunit gene expression, reflecting a lack of estrogen negative ... According to recent research from the United States, "Mice lacking estrogen receptor alpha in the pituitary gonadotroph (PitEsr1KO) were generated to determine the ...
2009 NOV 23 ... to recent research from the United States, "Delay to formalin fixation may invalidate hormone receptors and HER2 analyses. Invalid results of tumor markers could significantly alter ... invasive ductal carcinomas. Q score >or=6 was identified in five cases for estrogen receptor and four for progesterone receptor. Mean Q score started to decline at the 2 h mark for ...
2009 NOV 23 ... "The pro-opiomelanocortin (POMC)derived neuropeptide a-melanocyte-stimulating hormone (alpha-MSH) mediates its effects via melanocortin (MC) receptors. This study was carried ... for the expression of MC receptors, POMC, and prohormone convertases (PCs). MC-1 receptor (MC-1R) expression in articular cartilage was further studied by immunohistochemistry. ...
2009 NOV 23 ... implicated the renin angiotensin system in the cardiac hypertrophy induced by thyroid hormone. However, whether Angiotensin type 1 receptor (AT(1)R) is critically required to the ...
2009 NOV 24 ... According to recent research from the United States, "Growth hormone receptor knockout (GHRKO) mice live about 40%-55% longer than their normal (N) littermates. ...
2009 NOV 23 ... 3 receptor (MC3-R) has high affinity and specificity to gamma melanocyte-stimulating hormone (gamma MSH), a natriuretic peptide involved in regulation of blood pressure (BP) and ...
2009 NOV 23 ... levels initially increased, whereas levels of leucine-enkephalin did not change. Thyroid hormone receptor-alpha 1 protein expression in the heart decreased 1.6-fold after ALF, whereas myocardial ...
2009 NOV 23 ... cancer survivors in the US. Most breast cancers in women 50 years of age and older are hormone receptor positive," scientists in the United States report. "Third generation ...
2009 NOV 23 ... recent research published in the journal Biology of Reproduction, "Follicle-stimulating hormone (FSH) is the major regulator of folliculogenesis, but other factors modulate its action, ... isolated granulosa cells from Smad3-deficient animals had lower basal expression of FSH receptor (Fshr), aromatase (Cyp19a1), and cyclin D2 (Ccnd2) mRNA compared with WT mice. ...
2009 NOV 24 ... Mahon and colleagues published their study in Molecular Endocrinology (The Parathyroid Hormone 1 Receptor Directly Binds to the FERM Domain of Ezrin, an Interaction that Supports ...
2009 NOV 24 ... in females and critical for the female-typical cyclic surge pattern of luteinizing hormone (LH) release." "Sex differences in the size and function of the AVPV ... vitro follow-up studies. We found that the tumor necrosis factor alpha (TNF alpha)-TNF receptor 2 (TNFR2)-NF kappa B cell survival pathway is active in postnatal day 2 (PND2) female ...
2009 NOV 23 ... (TX) or aromatase inhibitors (AIs) has become the standard of care for treating hormone receptor -positive (HR+) breast cancer (BC) over the past 20 years. Based on clinical trial ...
