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2009 NOV 23 ... "Lung parenchymal strips isolated from ovalbumin-sensitized rats manifest a mast cell-dependent, biphasic contraction when challenged with allergen. The first phase is ...
2009 NOV 23 ... We measured the concentrations of potential mediators, including cytokines, chemokines, mast cell tryptase (MCT), and histamine, over 3 time points in 76 patients presenting to emergency ...
2009 NOV 23 ... IgE-mediated allergic conjunctivitis was initiated in C57BL/6-Kit(+/+) wild-type mice, mast cell-deficient Kit(W-sh/W-sh) mice, and Kit(W-sh/W-sh) mice that had been subconjunctivally ...
2009 NOV 23 ... to play a role in development and persistence of various inflammatory bladder disorders. Mast cell-derived tryptase specifically activates protease-activated receptor-2 (PAR-2), and PAR-2 ...
2009 NOV 16 ... was significantly increased expression of phosphorylated STAT5 and Akt in neoplastic mast cells although there was no change in the expression in other haemopoietic cells. JAK2 ... are characterised by mutations in genes encoding molecules or receptors involved in cell signalling, the most common being the JAK2 V617F mutation. This mutation leads to ...
2009 NOV 9 ... Serotonin, histamine and tryptase concentrations in supernatants and lamina propria mast cell density were determined. In contrast to controls, IBS supernatants significantly ...
2009 NOV 24 ... of China, "To determine whether changes in membrane potential affect the extent of mast cell degranulation, compound 48/80 was added to rat peritoneal...
2009 NOV 23 ... at d 10, 14, or 21. Sera were assayed for total IgE, BLG-specific IgG1, and rat mucosal mast cell protease II (RMCPII; indicator of mucosal mast cell ...
2009 NOV 16 ... upon serum injection," scientists in Rheinbach, Germany report. "Mast cell function depends on the release of granules filled with mediators such as histamine. ...
2009 NOV 16 ... as a fuel oxygenate commonly produced from bioethanol, on immunoglobulin (Ig)E-dependent mast cell activation was investigated. The rat mast cell line ...
2009 NOV 9 ... WASP-interacting protein and Arp2/3. KL-induced filopodia in bone marrow-derived mast cells (BMMCs) were significantly decreased in number and size in the absence of WASP. ... pleiotropic receptor tyrosine kinase Kit can provide cytoskeletal signals that define cell shape, positioning, and migration, but the underlying mechanisms are less well ...
2009 NOV 16 ... used in clinical trials to counteract neoplastic cell growth in patients with aggressive mast cell (MC) disorders. However, these patients suffer not only from MC infiltration and ...
2009 NOV 16 ... to a study from Oviedo, Spain, "Peripheral interactions between nociceptive fibers and mast cells contribute to inflammatory pain, but little is known about mechanisms mediating ... the skin, a phenotype that correlates with changes in the regulated cleavage of the cell-cell adhesion molecule N-cadherin. In contrast to basal nociception, Mmp24(-/-) mice do ...
2009 NOV 16 ... and colleagues. The researchers concluded: "Using immunohistochemistry for mast cell tryptase may be of value where there is doubt as to the nature of CD117-positive cells ...
2009 NOV 27 ... Chemistry (Synthesis and Evaluation of Lysophosphatidylserine Analogues as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy ...
2009 NOV 23 ... This review examines basic principles and recent research advances in the mechanisms of mast cell signaling believed to underlie anaphylaxis." "The unfolding complexity of ...
