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2009 NOV 23 ... the combination of AG 1478 and a transforming growth factor (TGF)beta(2) (1 mu g/ml)-neutralizing antibody, or with anti-TGF-beta(2) alone. Our findings demonstrate that short duration episodes ...
2009 NOV 23 ... in Oss, Netherlands report. "Here, the therapeutic potential of neutralizing CD97 in arthritis was studied with emphasis on the 1B2 pharmacokinetics. Mice with ... Degroot and colleagues published their study in the Journal of Immunology (Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, ...
2009 NOV 23 ... intake after BVDV type 1 challenge. Protection was determined by measuring the serum neutralizing (SN) antibody response in the fetus or calf and by virus isolation from thymus, lung, ...
2009 NOV 23 ... greater than 55 years of age, the probability of developing a fully protective neutralizing antibody response to the yearly multivalent particle inactivated influenza vaccine is less than ...
2009 NOV 23 ... The researchers concluded: "We propose that in response to variation in neutralizing antibody pressure between individuals, influenza A virus evolves by adjusting receptor binding ...
2009 NOV 16 ... of endothelial cells and neural progenitors. Blockade of Gal-3 activity by infusing a neutralizing antibody against Gal-3 into the ischemic striatum decreased ischemia-induced angiogenesis and the ...
2009 NOV 23 ... and interferon beta-treated patients with MS who tested positive and negative for neutralizing antibodies (NABs) were recruited from August 24, 2006, through December 15, 2006, for ... NAB-positive MS patients did not differ from untreated control donor individuals. Antibody titers inversely correlated with chemokine and chemokine receptor gene expression. ...
2009 NOV 23 ... and mediates membrane fusion to allow viral entry into target cells, thus eliciting neutralizing antibody response. The formation of the flavivirus prM/E complex is followed by the cleavage of ...
2009 NOV 16 ... DENV-4 similarly passaged in the same cells failed to elicit either viremia or a virus-neutralizing antibody response," scientists writing in the Journal of Virology report. ...
2009 NOV 23 ... with an immune-mediated demyelinating disease. Treatment of mice with anti-CXCL10 neutralizing antibody results in limited CD4+ T cell infiltration into the CNS accompanied by a reduction in ...
2009 NOV 16 ... mutate amino acids in seven key epitopic toxin regions that dictate B-cell generation of neutralizing antitoxin antibodies. Bioassays were used to determine whether mutation reduced potency, ... using mutagenesis, measure the ability of mutated drug to elicit B-cell antitoxin antibody responses, and show that mutated drug was effective against systemic breast cancer in ...
2009 NOV 28 ... powerful antibodies against HIV, 2F5 and 4E10. Both of these are rare, broadly neutralizing antibodies, meaning that they can block a number of different strains of the HIV virus. ... study clearly showed that we've been overlooking a very important component of antibody function," says S. Munir Alam, Ph.D., an associate professor of medicine at Duke ...
2009 NOV 23 ... The researchers concluded: "Importantly, using an alpha 2 beta 1-neutralizing antibody, we demonstrated that SEMA3A suppression of tumor cell migration is dependent on alpha 2 ...
2009 NOV 23 ... incubation with thiol/PDI inhibitors DTNB, bacitracin, phenylarsine oxide, and neutralizing PDI antibody in a parasite redox-dependent way. Binding assays indicate that PDI ...
2009 NOV 16 ... was induced in Long Evans rats with streptozotocin, and an anti-alpha 4 integrin/CD49d neutralizing antibody was injected 5 and 10 days later. Two weeks after streptozotocin administration, ...
2009 NOV 16 ... found that m102.4 was well tolerated, exhibited no adverse effects and retained high neutralizing activity. The findings suggested that m102.4 could potentially be used as a preventive ... viruses, the team of researchers demonstrated that giving an anti-virus human monoclonal antibody therapy after exposure to Nipah virus protected the animals from disease. ...
Subject: Henry M. Jackson Foundation for the Advancement of Military Medicine
