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2009 NOV 27 ... directly in catalysis Defining the functional role of the nucleobase requires nucleoside analogues that perturb the functional groups in a strategic manner. Herein, we have ...
2009 NOV 23 ... metastatic disease. A number of recent studies have shown that activation of the purine nucleoside receptor, adenosine A(3) receptor (A(3)AR), attenuates proliferation of melanoma, colon, ...
2009 NOV 28 ... in vitro studies have demonstrated that FV-100, an orally available bicyclic nucleoside analogue, is significantly more potent against VZV, and can inhibit its replication ...
2009 NOV 23 ... phosphorylase II from Sulfolobus solfataricus (SsMTAPII) and purine nucleoside phosphorylase from Pyrococcus furiosus (PfPNP) are hyperthermophilic purine...
2009 NOV 23 ... inhibitor of hepatitis B virus (HBV) polymerase. The efficacy and safety of entecavir in nucleoside-naive patients with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B was ...
2009 NOV 23 ... hippocampal neurons. BDNF changed the abundance of proteins involved in (i) Nucleobase, nucleoside, nucleotide and nucleic acid metabolism, (ii) protein metabolism, (iii) carbohydrate ...
2009 NOV 16 ... the antiviral activity of SCY-635 in combination with approved and investigational non-nucleoside polymerase inhibitors, nucleoside polymerase ...
2009 NOV 16 ... for effective inhibition of a paramyxovirus RdRp complex through interaction of a non-nucleoside small-molecule inhibitor with the L protein. Resistance mutations are located in regions ...
2009 NOV 16 ... Chemmedchem (Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Chemmedchem, 2009;4(9):1537-1545). ...
2009 NOV 16 ... "To review the pharmacology, pharmacokinetics, efficacy, and safety of apricitabine, a nucleoside reverse transcriptase inhibitor that is currently under investigation and has fast-track ...
2009 NOV 16 ... conditions. The prosurvival autophagic response of myeloma to nutrient deprivation or to nucleoside analogue treatment has not been described previously," wrote M. Shanmugam and ...
2009 NOV 23 ... "Gemcitabine (2',2'-difluorodeoxyribofuranosylcytosine) is an anticancer nucleoside analogue active against a wide variety of solid tumors. However, following intravenous ...
2009 NOV 16 ... naive and experienced patients - with a twice daily oral combination therapy of a nucleoside polymerase and protease inhibitor. The results were significant antiviral potency and ...
