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2009 NOV 27 ... researchers concluded: "These phosphoramidites were incorporated into oligonucleotides by solid-phase synthesis."Lu and colleagues published their study in the ...
2009 NOV 25 ... UNA products enable the fine-tuning of the duplex thermodynamic stability of oligonucleotides with applications in areas such as improved siRNA gene silencing.Professor ...
2009 NOV 23 ... at pH 7.4 and 50 degrees C. Peptide sequencing facilitated the design of degenerate oligonucleotides from homologous sequences encoding putative fungal proline aminopeptidases, enabling ...
2009 NOV 17 ... the number of cells in S phase during ESCs differentiation (P < 0.05). Antisense oligonucleotides of has-miR-222 could increase reporter gene expression by targeting the 3' untranslated ...
2009 NOV 23 ... carriers that can overcome the multiple barriers associated with the delivery of oligonucleotides from the site of administration to the nucleus or cytoplasm of the target cell." ...
2009 NOV 23 ... functions of these microRNAs in lymphomagenesis, we examined the effects of antisense oligonucleotides (ASOs) targeting miR-21 (ASO-21) and/or miR-155 (ASO-155) in NK-cell lymphoma lines ...
2009 NOV 16 ... by mutations in the DMD gene that abolish the synthesis of dystrophin protein. Antisense oligonucleotides (AOs) targeted to trigger excision of an exon bearing a mutant premature stop codon in ...
2009 NOV 16 ... steps from commercially available compounds, and its binding to CTG and CUG repeats in oligonucleotides studied. Isothermal titration calorimetry studies of 1 with various sequences showed a ...
2009 NOV 27 ... a bimolecular quenching constant of K-s = 52.3 M-1. The fluorescence of TMR in labeled oligonucleotides decreases efficiently through photoinduced electron transfer by guanosine. The quenching ...
2009 NOV 16 ... or stability. Interestingly, capsid reassembly can be induced by polyanions, including oligonucleotides, poly-glutamic acid, and nonbiological polymer (polyacrylic acid). In contrast, ...
2009 NOV 23 ... "A series of substrate DNA complexes have been formed using native oligonucleotides and bridged ones bearing non-nucleotide inserts based on phosphodiesters of di-, tetra-, ...
2009 NOV 16 ... utility of PCR amplification followed by analysis of DNA microarray carrying specific oligonucleotides," researchers in Fukui, Japan report. "This study included 101 biological ...
2009 NOV 16 ... (Strasbourg, France) to manufacture and commercialize Zip Nucleic Acid (ZNA™*) oligonucleotides, a new technology that provides solutions for increased affinity for nucleic acids. ...
2009 NOV 27 ... to the early detection of protein biomarkers.""Aptamers are synthetic oligonucleotides that have undergone iterative rounds of in vitro selection for binding with high ...
2009 NOV 23 ... "We present the first separation of single-stranded and double-stranded oligonucleotides in a nanofluidic device. We couple this separation with free-solution hybridization to ...