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2009 NOV 23 ... Stapled Peptides can potently and directly inhibit the transcription factor Notch, an oncogene implicated in cancer cell proliferation and survival. This research validates the ...
2009 NOV 23 ... (FDA). CEQ508, an orally administered tkRNAi drug candidate, targets beta-catenin, a key oncogene implicated in the formation of colonic polyps and in the progression of polyps to ...
2009 NOV 23 ... of some organochlorine compounds (OCs) and the mutational status of the KRAS oncogene, as well as among the latter and coffee intake." "Incident cases of PDA ...
2009 NOV 23 ... prolonged survival was observed. Thus, p16(INK4a) is a negative regulator of the IGFBP2 oncogene," wrote L.M. Moore and colleagues, University of Texas. The researchers ...
2009 NOV 23 ... prediction at the 3' untranslated region of the pleomorphic adenoma gene 1 (PLAG1) oncogene. Luciferase reporter assays including site-directed mutagenesis of binding sites ...
2009 NOV 17 ... detected in vitro protease activity for another CXC chemokine GRO-alpha (growth-related oncogene alpha), but not for NAP-2 (neutrophil-activating protein 2), SDF (stromal-cell-derived ...
2009 NOV 23 ... and sufficient to transcriptionally repress cMYC, the most commonly overexpressed oncogene in prostate cancer as well as among the aggregates of other cancers. FOXP3 is an ...
2009 NOV 23 ... in PanINs, likely in response to the accumulating DNA damage from events such as oncogene mutations and telomere dysfunction," wrote J.B. Koorstra and colleagues, Johns Hopkins ...
2009 NOV 23 ... or VL30-1 RNA." "The results are as follows: (i) PSF binds to the proto-oncogene Rab23, repressing transcription, and VL30-1 RNA binds and releases PSF from Rab23, ...
2009 NOV 16 ... published their study in the Journal of Cellular and Molecular Medicine (Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of ...
2009 NOV 16 ... According to a study from South Korea, "CD24 has emerged as a new oncogene and metastasis promoter. However, there is a controversy as to whether CD24 expression ...
2009 NOV 16 ... Originally, iPS were induced by a stemness-related gene set that included the c-MYC oncogene." "Here, we determined from embryo to adult the cardiogenic proficiency ...
2009 NOV 16 ... of PIs in treating NSCLC." Yuan and colleagues published their study in Oncogene (Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive ...
2009 NOV 24 ... the neighboring tissues and, when combined with an activated form of the Ras proto-oncogene, they trigger the formation of metastases. PcG proteins bind to multiple genes in the ...
2009 NOV 16 ... Finally, TR alpha suppresses NIH-3T3 fibroblast transformation by the Ras oncogene both in a ligand-dependent and -independent manner, but the CTE mutant is unable to ...
2009 NOV 16 ... upstream element binding protein 1 (FBP1), an activator of transcription of the proto-oncogene c-myc, in a functional yeast survival screen for tumor-related antiapoptotic proteins ...
2009 NOV 16 ... "Studies of human genetic variants in the p53 tumor suppressor gene and MDM2 oncogene have shown that single nucleotide polymorphisms (SNP) can affect p53 signaling, confer ...
2009 NOV 16 ... region of a chromosome arm, and is a mechanism for acquired drug resistance and oncogene activation. In multiple myeloma (MM), high CNs of genes in a 1q12 approximately 23 ...
2009 NOV 16 ... According to a study from the United States, "The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is ...
