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2009 NOV 23 ... that inactivation of a DNA repair gene called Hus1 efficiently kills cells lacking p53 -- a gene mutated in the majority of human cancers. Using a mouse model, ...
2009 NOV 23 ... because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations ... production of TAp63 proteins, which make up one class of proteins produced by the p63 gene. TAp63 completely blocked tumor initiation, the team found, by inducing senescence, a ...
2009 NOV 16 ... reflecting the success of our proprietary programs." QPI-1002 targets p53, a stress-response gene that plays a pivotal role in the apoptotic pathway. Temporary ...
2009 NOV 16 ... "The role of miR-34a, a p53-regulated microRNA, in retinoblastoma (RB) was investigated. The expression of miR-34 ... was not caused by genomic alterations at the miR-34a p53 binding site or mature gene. Exogenous miR-34a inhibited Y79 and Weri-Rb1 cell growth and increased apoptotic ...
2009 NOV 16 ... associated with protection from both cardiovascular and all-cause mortality. p53 regulates mitochondrial function and its deletion markedly diminishes exercise capacity, ... p53 interacts with Mitochondrial Transcription Factor A (TFAM), a nuclear-encoded gene important for mitochondrial DNA ( mtDNA) transcription and maintenance, and regulates ...
2009 NOV 20 ... STAT5) and increased expression of p21 and cyclin D1, whereas no expression of either p53 or cyclin D3 could be detected. This mechanism was present in ACH children carrying the ... of dwarfism and is due to mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. The cellular mechanisms involved in the reduced growth have been mainly described for ...
2009 NOV 23 ... of oncogenes, such as Her2/neu, or loss of function of tumor suppressor genes, such as p53, are known to be associated with poor prognosis, but additional factors influencing ... between low-grade and high-grade endometrioid endometrial adenocarcinomas, we compared gene expression in these 2 types of tumors. Six well-differentiated adenocarcinomas and 7 ...
2009 NOV 16 ... of irreversible growth arrest thought to act as a barrier to cancer development. The p53 tumor suppressor is a critical mediator of senescence and recent in vivo studies have ... control. Retinoblastoma family members (pRb, p107, and p130) previously implicated in gene silencing during fibroblasts senescence were found down-regulated in cells with ...
2009 NOV 16 ... of extending the cellular life span by sequestering tumor suppressor proteins pRB and p53 in virus-transformed human cells." "Although SV40 large T antigen is ... According to a study from the United States, "We have applied a functional gene transfer strategy to show the importance of viral integration site in cellular ...
2009 NOV 23 ... resulting from DNA damage or DNA-repair gene mutations(1-12). Here, we report that p53 deficiency severely exacerbates tissue degeneration caused by mosaic deletion of the ...
2009 NOV 16 ... Researchers detail in 'Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell ... and suppression of breast cancer cell proliferation,' new data in cancer gene therapy. According to recent research from London, the United Kingdom, "The nerve ...
2009 NOV 23 ... transfected with mPer2. RT-PCR analysis showed an increased expression of bax, bcl-2, p53, c-myc, mre11, and nbs1, and an increased proportionality of bcl-2/bax in the irradiated ... "Period2 is a core circadian gene, which not only maintains the circadian rhythm of cells but also regulates some organic ...
2009 NOV 23 ... a severe decline in cell proliferation in 5637 and SW1710 cell lines, both with mutant p53. Apoptosis was more strongly enhanced in 5637 cells lacking RB1 than in SW1710 cells ... apoptosis in the bladder cancer cell lines 5637 and SW1710.' "The Nucleostemin (NS) gene encodes a nucleolar protein enriched in adult and embryonic stem cells. NS is thought to ...
2009 NOV 16 ... According to a study from Oxford, the United Kingdom, "A regulated p53-dependent stress response is crucial in suppressing tumor formation and mediating the ... pathway." "Studies of human genetic variants in the p53 tumor suppressor gene and MDM2 oncogene have shown that single nucleotide polymorphisms (SNP) can affect p53 ...
2009 NOV 23 ... Cancer Research and Treatment (Biological significance of allele specific loss of the p53 gene in breast carcinomas. Breast Cancer Research and Treatment, 2009;118(1):15-20). ...
2009 NOV 16 ... research published in the Biochemical Journal, "Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of ...
