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2009 NOV 23 ... in Breast Cancer Research and Treatment (A 7 Mb region within 11q13 may contain a high penetrance gene for breast cancer. Breast Cancer Research and Treatment, 2009;118(1):151-159). ...
2009 NOV 23 ... be eliminated, this meta-analysis supported that the APE1 T1349G polymorphism is a low-penetrance risk factor for cancer development." Gu and colleagues published their ...
2009 NOV 3 ... According to a study from Delhi, India, "Incomplete penetrance and variable expressivity are non-Mendelian phenomena resulting in the lack of ...
2009 NOV 24 ... patient was also a carrier for the R143Q, indicating that this mutation has incomplete penetrance," wrote M. Bonyadi and colleagues. The researchers concluded: "Our ...
2009 NOV 23 ... These mice show myometrial hyperplasia and develop mesenchymal tumors with 100% penetrance that exhibit histological and molecular characteristics of human leiomyomas and ...
2009 NOV 23 ... "However, Insulin2 (Ins2) knockout NOD mice develop autoimmune diabetes with complete penetrance in both sexes, at an earlier age, and have stronger autoimmune responses to insulin. The ...
2009 NOV 9 ... other's positive effect on splicing. The most severe TBX5 mutation, G80R, with complete penetrance of the cardiac phenotype, strongly affects pre-mRNA splicing, whereas other mutations ...
2009 NOV 2 ... to atherosclerosis is being performed, with the resulting data analyzed for rare, high-penetrance variants associated with specific clinical traits. The participants are also being ...
2009 NOV 2 ... common and pedigrees in these cases suggest an autosomal-dominant transmission with high penetrance. Genetic investigations have been performed in order to identify genes associated with ...
2009 NOV 9 ... zinc finger protein 350 (ZNF350) work with BRCA1 in tumor suppression procedures. Low penetrance variants of these three genes may jointly affect individuals' breast cancer ...
2009 NOV 2 ... Fresh data on colon cancer are presented in the report 'Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.' According to recent ...
2009 NOV 20 ... and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree of penetrance, such that more than 95% of patients develop clinical manifestations by the fifth ...
2009 NOV 3 ... (phenotypic) prevalence could be due to the existence of non-pathological or low penetrance alleles, which may result in late-onset arSTGD or may be implicated in age-related ...
2009 NOV 23 ... from approaches designed to detect risk variants with relatively low frequency and high penetrance in a well-defined and relatively homogeneous population, provide strong empirical ...
2009 NOV 16 ... by a recurrent dominant mutation in the GHRHR signal peptide associated with incomplete penetrance. (J Clin Endocrinol Metab 94: 3939-3947, 2009)." Godi and colleagues ...
2009 NOV 23 ... but not in the APOE epsilon 4 noncarrier. Two additional cases exhibited incomplete penetrance, as they had no clinical evidence of CJD at death after age 80 years but had affected ...
2009 NOV 16 ... treatment of murine models of disease, so that gender-related variations in genetic penetrance are not mistaken for disease correction." Tolar and colleagues published ...
2009 NOV 10 ... The researchers concluded: "It seems that TRPC6 is a gene with a very variable penetrance that may contribute to glomerular diseases in a multi-hit setting." Santin ...
2009 NOV 2 ... unique opportunities to study the effect of other genetic and environmental factors on penetrance and disease phenotype." Papi and colleagues published their study in ...
