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2009 NOV 2 ... gliosis marked by the deposition of fibrils composed of GFAP is a prominent feature of prion disease, we asked whether GFAP might be used as a surrogate marker for prions," ...
2009 NOV 2 ... "To obtain high titer monoclonal antibodies (McAbs) which can react with mammalian prion protein (PrP), Balb/C mice were immunized with bovine (Bo) PrP peptide (BoPrP 209-228 ...
2009 NOV 23 ... Jakob Disease, Creutzfeldt-Jakob Disease, Enolase, Enzymes, Genetics, Neurology, Prion Disease, University of Gottingen. This article was prepared by Pain & ...
2009 NOV 9 ... to a study from Warsaw, Poland, "In previous studies we have demonstrated that prion protein (PrP) binds directly to tubulin and this interaction leads to the inhibition of ...
2009 NOV 16 ... treatment of transmissible spongiform encephalopathies. Direct binding to the cellular prion protein (PrPC) has been proposed as anti-prion active ...
2009 NOV 9 ... architecture, which is common to many human disease-associated amyloids and the yeast prion amyloids," wrote F. Shewmaker and colleagues, National Institute of Diabetes and ...
2009 NOV 16 ... "HECTD2 maps to 10q and has been implicated in susceptibility to human prion diseases which are also neurodegenerative conditions associated with accumulation of ...
2009 NOV 2 ... agglutinin-1 binding to M cells. Whole-mount immunostaining also revealed that cellular prion protein (PrPC) was expressed on the luminal side of the apical plasma membrane of M ...
2009 NOV 10 ... homologies between ST1859 (1[(2-hydroxy-1-naphtyl)methyl]-2-naphthol) and the anti-prion agents and its anti-amyloidogenic activity, we tested whether this molecule altered the ...
2009 NOV 3 ... to recent research published in the journal Nature Structural & Molecular Biology, "In prion inheritance and transmission, strains are phenotypic variants encoded by protein ...
2009 NOV 2 ... (Localization of disease-related PrP in Danish patients with different subtypes of prion disease. Clinical Neuropathology, 2009;28(5):321-332). For more ...
2009 NOV 2 ... progressive dementia and myoclonus, and it is caused by a conformational change of the prion protein. The heritable forms are associated with mutation in the gene encoding the...
2009 NOV 23 ... disease (CJD) represents 5% to 15% of all CJD cases. The E200K mutation in the prion protein (PrP) gene (PRNP) is the most frequent cause of familial CJD." ...
2009 NOV 16 ... "Since it was posited that a cytoplasmic isoform of PrP may be involved in prion diseases, controversies about the isoform's biogenesis and function have emerged in the ...
2009 NOV 16 ... is an early and major component of a number of neurodegenerative diseases. Murine prion disease offers a tractable preparation in which to study synaptic loss in a chronic ...
2009 NOV 17 ... and the 1994 Albert Lasker Award for Basic Medical Research ─ both for his Prion research. Prusiner discovered prions, a class of infectious self-reproducing pathogens ...
