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2009 AUG 31 ... Charcot-Marie-Tooth disease, type 1 repeat element, sex-determining region Y, or short tandem repeats (STR) across human leukocyte antigen (HLA) regions, which are distinct from ... their value relative to one another had not been defined. We examined whether human sequences in chimeric mice could be measured with quantitative real-time polymerase chain ...
2009 NOV 2 ... A report, 'T-REKS: identification of Tandem REpeats in sequences with a K-meanS based algorithm,' is newly published data in ... on several sequence datasets is presented. Our program being linked to the Protein Repeat DataBase opens the way for large-scale analysis of protein tandem repeats. T-REKS can ...
2009 AUG 25 ... Polycomb group complex as well as a distally located methylated region containing a tandem triple repeat sequence." "In this study, we investigated the regulation ... is regulated by genomic imprinting, which is likely caused by the presence of repeat sequences in the proximity of the PHERES1 locus.." Villar and colleagues published ...
2009 APR 13 ... Journal of Clinical Microbiology report.
"Microsatellites are short tandem repeats of 1- to 6-nucleotide motifs; they are often highly variable and polymorphic ... microsatellites, 45 were found to be distributed in intergenic or noncoding inverted repeat regions, while 34 were in open reading frames. Length polymorphism analysis of the PCR ... double-stranded DNA of 152 kpb. It is divided into long and short regions of unique sequences termed U-L and U-S, respectively, and these are flanked by regions of inverted internal ...
2009 JUN 16 ... element. Inhibitors of the MEK1/2-ERK pathway did not alter HRV-16-induced activation of tandemrepeat kappa B1 or kappa B2 constructs, nor did they alter HRV-16-induced nuclear ... nuclear translocation/binding of NF-kappa B to either kappa B1 or KB2 recognition sequences. Furthermore, PD98059 and U0126 did not alter phosphorylation or degradation of I kappa ...
2009 JUN 16 ... The data further revealed diversification of ankyrin repeat genes by short tandem duplications and provided examples of horizontal gene transfer across A- and B- group ... melanogaster identified 35 breakpoints associated with mobile elements and repeated sequences that are stable in Drosophila lines transinfected with wRi. Additionally, 450 genes with ...
2009 NOV 24 ... 55 bp sequences separated by 158 bp, and the D lunatus A+T-rich region harbors a tandemrepeat comprising two identical 261 bp copies and one partial copy of the repeat," ...
2009 AUG 17 ... scientists in the United States report. "Engineered ZFNs use a tandem array of zinc fingers, fused to the FokI DNA cleavage domain, to direct double-strand ... skeletal disorders. To examine the contribution of double-strand break repair to CAG.CTG repeat instability in mammalian systems, we developed zinc finger nucleases (ZFNs) that ... systems, we developed zinc finger nucleases (ZFNs) that recognize and cleave CAG repeat sequences," scientists in the United States report. "Engineered ZFNs use a tandem ...
2009 AUG 4 ... of Georgia. The researchers concluded: "A database including all tandem repeat sequences characterized here was created to benefit future comparative genomic analyses." ...
2009 APR 6 ... from other cats with AML, differs from the LTRs of other known FeLV in that it has 3 tandem direct 47-bp repeats in the upstream region of the enhancer (URE)."
... was obtained from a domestic cat with acute myeloid leukemia (AML). The long terminal repeat (LTR) of this virus, like the LTRs present in FeLV from other cats with AML, differs ... of the apoptosis-related genes TNF-alpha and survivin. Analysis of the proviral sequences obtained from 13 cats with naturally occurring MDS reveal they also bear the ...
2009 NOV 23 ... were compared. Both cell lines are indistinguishable on the basis of highly polymorphic tandemrepeat DNA sequences," investigators in Hamburg, Germany report. ...
2009 SEP 21 ... CB plasma in quality and quantity able to support human genetic identification by short tandemrepeat analysis (STR). The presence of extracellular DNA (EC-DNA) in CB and adult ... not been used for CB plasma." "We have previously reported that viral DNA sequences are present in the CB plasma of carrier babies and now hypothesize that human genomic ...
2009 SEP 1 ... approach to analyze their duplication/expansion and function. The analyses show that tandem/segmental duplication and transposition/retrotransposition have significantly ... been detected from retrogene, tandem, segmental, Pack-MULE, or long terminated direct repeat-related duplication/expansion. The nonsynonymous substitutions per site and synonymous ... that most of the hypothetical genes could be annotated from recently evolved genomic sequences. These data advance the understanding of rice hypothetical genes as being involved in ...
2009 JUL 6 ... their study in the Journal of Molecular Evolution (Structure and Conservation of Tandem Repeats in the Mitochondrial DNA Control Region of the Least Brook Lamprey (Lampetra ... "We report phylogenetic and geographic patterns of variation of control region repeat sequence and number in a nonparasitic lamprey, Lampetra aepyptera. A survey of ... recent research published in the Journal of Molecular Evolution, "Tandemly repeated sequences are a common feature of vertebrate mitochondrial DNA control regions. However, questions ...
2009 MAY 5 ... "Previously, we showed that the G564 upstream region has a block of tandem repeats, which contain a conserved 10-bp motif (GAAAAGC/TGAA), and that deletion of ... transcription. Fine-scale deletion and scanning mutagenesis experiments with 1 tandem repeat uncovered a 54-bp region that contains all of the sequences required to activate ...
2009 AUG 25 ... of mRNA molecules. Although the SL RNA gene was shown initially to be organized as tandem repeats with transcripts of 50-60 nt, shorter than most of their counterparts in other ... The researchers concluded: "These results suggest that 1) both the SL RNA tandem repeat and the SL-5S cluster genomic organizations are an "ancient" and widespread feature ... Biology and Evolution (Dinoflagellate Spliced Leader RNA Genes Display a Variety of Sequences and Genomic Arrangements. Molecular Biology and Evolution, 2009;26(8):1757-1771). ...
2009 JUN 23 ... the United States report.
"As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of ...
2009 AUG 18 ... here the crystal structure of a dimeric mutant of SeqA [SeqA(4159)-A25R] bound to tandem hemimethylated GATC sites. The structure delineates how SeqA forms a high-affinity ... Research (Structural insights into the cooperative binding of SeqA to a tandem GATC repeat. Nucleic Acids Research, 2009;37(10):3143-3152). For additional ... SeqA exerts its functions by binding clusters of transiently hemimethylated GATC sequences generated during replication. However, the molecular mechanisms that trigger formation ...
2009 OCT 6 ... allele consists of eleven nearly perfect P1-wr 12-kb repeats that are arranged in a tandem head-to-tail array. Although a technical challenge to sequence such a structure by ... such a structure by shotgun sequencing, we overcame this problem by subcloning each repeat and ordering them based on nucleotide variations. These polymorphisms were also critical ... comparisons among orthologous and paralogous genes and their allelic variants can reveal sequences of functional significance," scientists writing in the journal Plos Genetics report. ...
2009 SEP 15 ... for class switch recombination (CSR) events that occur in mice that lack the S mu tandemrepeat (S mu TR) region (S mu TR-/- mice). The pattern of microhomology among switch ... sites in Msh2-deficient mice is also dependent on the presence or absence of S mu TR sequences." "It is not known whether these CSR effects reflect an individual ...
