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2009 SEP 14 ... industry. Enantioselectivity of this lipase was improved by site-directed mutagenesistargeted to the substrate binding site." "To guide mutagenesis experiments, the ...
2009 NOV 17 ... silencing of all the target genes was confirmed. Furthermore, when antisense RNAs were targeted to the mutator genes mutS, mutD (dnaQ) and ndk, which are involved in DNA replication or ... frequencies increased over 2000-fold. The resulting mutator strain is useful for random mutagenesis of plasmids," wrote N. Nakashima and colleagues. The researchers ...
2009 AUG 3 ... the modeled structure of ytCBS. Residues E136, H138, Y248, and D249 of ytCBS were also targeted as they correspond to identical polar residues lining the mouth of the active site in ... in Ottawa, Canada report. "Residue K112 was selected for site-directed mutagenesis based on the results of the in silico docking of L-Cth to the modeled structure of ...
2009 NOV 2 ... "These results indicate that vaccine candidates can be developed by introducing targeted mutations to disrupt motifs in proteins responsible for inhibition of the interferon ... attenuated vaccine candidates are developed by repeated passage or random mutagenesis. Defining the mechanisms underlying attenuation can lead to more sophisticated ...
2009 OCT 12 ... generating a pre-DG of about 160 kDa. This uncleaved pre-DG tetramutant is properly targeted at the cell membrane, is partially glycosylated and still binds laminin in pull-down ... no ultimate structural data are yet available on the alpha-beta interface, site-directed mutagenesis was used to identify which specific amino acids are involved in the interaction. A ...
2009 SEP 7 ... yielded a substrate that is cleaved seven times more efficiently by LF than the peptide targeted in the protein kinase MKK6. Site-directed mutagenesis within the metal-binding site in ...
2009 OCT 12 ... tumors has been well correlated with clinical outcome in patients receiving micro tubule-targeted agents, the regulation of this protein remains poorly understood. Recently, new insight ... of the beta 3-tubulin gene promoter by successive deletions followed by site-directed mutagenesis led to the localization of a vinorelbine-responsive element containing an ...
2009 OCT 5 ... of influenza A viruses forms a tetrameric pH-activated proton-selective channel that is targeted by the amantadine class of antiviral drugs." "Its ion channel function ... "Its ion channel function has been extensively studied by electrophysiology and mutagenesis; however, the molecular mechanism of proton transport is still elusive, and the ...
2009 AUG 24 ... efficient capture of PCR amplicons. Upstream and downstream DNA sequences flanking genes targeted for deletion were cloned together in a single step. Based on results from Vibrio ... (USER Friendly Cloning Coupled with Chitin-Based Natural Transformation Enables Rapid Mutagenesis of Vibrio vulnificus. Applied and Environmental Microbiology, 2009;75(15):4936-4949). ...
2009 AUG 17 ... writing in the journal Current Genetics report. "We analyzed the targeted insertion mutagenesis method in the budding yeast Saccharomyces castellii, ...
2009 OCT 12 ... for identifying genes and pathways that modulate how primary cancer cells respond to targeted therapeutics and for probing mechanisms of de novo and acquired resistance." ... leukaemias (AMLs) in which cooperating mutations were induced by retroviral insertional mutagenesis. Here we show that MEK inhibitors are ineffective in MPD, but induce objective ...
2009 NOV 2 ... factor 8 (Irf8), which induces a myeloproliferation in vivo." "Among the targeted genes, we identified Mef2c, encoding a MCM1-agamousdeficiens-serum response factor ... self-renewal potential coupled to an aberrant differentiation program. Using retroviral mutagenesis, we identified genes that generate LSCs in collaboration with genetic disruption of the ...
2009 NOV 16 ... and lend support to the idea that it evolved to evade bacterial resistance mechanisms targeted at the cationic character of most AMPs," wrote M. Li and colleagues, National ... to dermcidin. To that end, we constructed a plasmid for use in mariner-based transposon mutagenesis and developed a high-throughput cell viability screening method based on luminescence. ...
2009 AUG 3 ... produces long chain polyunsaturated fatty acids (PUFAs) via a PUFA synthase. Targeted mutagenesis of one gene of this synthase was conducted to confirm PUFA synthase function and ...
2009 AUG 17 ... and neighboring cells. We hypothesized that transposon mutagenesis would complement targeted knockout studies in Geobacter spp. and identify novel genes involved in this process," ...
2009 SEP 14 ... mice in which TEL-AML1 expression is driven from the endogenous promoter and can be targeted to specific populations. TEL-AML1 renders mice prone to malignancy after chemical ... to specific populations. TEL-AML1 renders mice prone to malignancy after chemical mutagenesis when expressed in hematopoietic stem cells (HSCs), but not in early lymphoid ...
2009 OCT 19 ... MLV-infected BALB/c mice, intron 2 of the AP-1 repressor Jdp2 locus was found frequently targeted by proviruses resulting in upregulation of non-canonical RNA subspecies. We identified ... research published in the journal Nucleic Acids Research, "Retroviral insertional mutagenesis has been instrumental for the identification of genes important in cancer development. ...
2009 NOV 16 ... published article, scientists in the United States conducted a study "To develop a targeted biological drug that when systemically injected can penetrate to metastatic breast ... COOH terminus." "Our purpose was to reduce toxin immunogenicity using mutagenesis, measure the ability of mutated drug to elicit B-cell antitoxin antibody responses, and ...
2009 SEP 14 ... was also achieved at the endogenous PIG-A locus, with a> 200-fold enhancement by ZFNs targeted to that gene. Clonal PIG-A null hESCs and iPSCs with normal karyotypes were readily ... alterations in stem cell karyotypes or pluripotency. Efficient HR-mediated insertional mutagenesis was also achieved at the endogenous PIG-A locus, with a> 200-fold enhancement by ZFNs ...
2009 AUG 11 ... According to a study from the United States, "We have demonstrated that targeted mutagenesis can be accomplished in maize plants by excision, activation, and subsequent elimination ...
