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2009 NOV 24 ... double-knockout MEFs, we show that MRN is required for ATM signaling in response to telomere dysfunction." "This establishes that MRN is the only sensor for the ATM ...
2009 NOV 24 ... Mre11 and Nbs1 mutants (Mre11(ATLD1/ATLD1) and Nbs1(Delta B/Delta B), respectively). No telomere shortening was observed in Mre11(ATLD1/ATLD1) cells after extensive passage through ...
2009 NOV 23 ... "In all telomerases, the template region of the RNA subunit contains a region of telomere homology that is longer than the unit telomeric repeat. This allows a newly synthesized ...
2009 NOV 16 ... mesenchymal stem cell origin for ALT,' are detailed in a study published in Oncogene. "Telomere length is maintained by two known mechanisms, the activation of telomerase or ...
2009 NOV 23 ... cancers do not show evidence of telomerase activity, and a subset of these maintain telomere lengths by a recombination-based mechanism termed alternative lengthening of telomeres ...
2009 NOV 23 ... was conducted to comprehensively evaluate the associations between polymorphisms in telomere maintenance genes (TERT, TRF1, TNKS1, TRF2, RAP1, and POT1) and lung cancer risk. We ...
2009 NOV 23 ... insulin-like-growth factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte...
2009 NOV 16 ... LPL ( Lipoprotein lipase) and Leptin. Attempt has also been made to find out whether telomere length attrition is associated with hypertension and obese individuals." ...
2009 NOV 16 ... stasis via silencing of p16 expression and that display senescence associated with telomere dysfunction. Cultured pre-stasis populations contained cells expressing markers ...
2009 NOV 16 ... According to a study from Milan, Italy, "Telomere shortening in blood leukocytes has been associated with increased morbidity and death ...
2009 NOV 16 ... "Eukaryotic DNA is packaged into chromatin, which regulates genome activities such as telomere maintenance. This study focuses on the interactions of a myb/SANT DNA-binding domain ...
2009 NOV 23 ... DNA (ssDNA)-binding activity of the human telomeric protein POT1 induces significant telomere elongation, suggesting that at least one critical aspect of the regulation of...
2009 NOV 23 ... in response to the accumulating DNA damage from events such as oncogene mutations and telomere dysfunction," wrote J.B. Koorstra and colleagues, Johns Hopkins University, Sol Goldman ...
2009 NOV 23 ... of Applied Animal Research, "A fundamental observation of replicative senescence is the telomere shortening in many species. The objective of this paper is to investigate the ...
2009 NOV 16 ... in North America, is caused by the spirochetal pathogen Borrelia burgdorferi. The telomere resolvase encoded by this organism (ResT) promotes the formation of covalently closed ...
2009 NOV 23 ... diabetes, we will also examine current literature regarding the effects of diabetes on telomere shortening and provide insights from our own studies on the role of telomerase in ...
2009 NOV 23 ... in preserving chromosomal integrity and genomic stability; their shortening can lead to telomere dysfunction and chromosomal instability, a critical factor in cancer development," ...
