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2009 NOV 2 ... in response to chemicals and drugs is a common regulatory concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic basis, but many mechanism-based ...
2009 OCT 19 ... Pharmacology (The Aldo-Keto Reductase Akr1b7 Gene Is a Common Transcriptional Target of Xenobiotic Receptors Pregnane X Receptor and Constitutive Androstane Receptor. Molecular ...
2009 OCT 19 ... putative GC box consensus sequences were recognized in positions - 181 and - 460, and xenobiotic-responsive elements in positions - 107, - 277 and - 390. The isolation of a second cDNA ...
2009 NOV 2 ... Spodoptera larvae in vivo. The assay was evaluated using phenylhydrazine, the well-known xenobiotic which induces haemolysis in mammals." "Haemocyte disintegration causes ...
2009 OCT 19 ... proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34). Unlike most UGT1A and UGT2B xenobiotic-metabolizing enzymes, UGT1A4 and UGT2B10 lack the ability to glucuronidate ...
2009 OCT 19 ... either with a 1% cholic acid-supplemented diet or a diet containing the porphyrinogenic xenobiotic 3,5-diethoxycarbonyl-1,4-dihydrocollidine to determine the effect of K8/K18 loss on bile ...
2009 NOV 2 ... suspensions are a well established in-vitro model for studying drug transport and xenobiotic metabolism. Therefore, the hepatic uptake of paclitaxel and its P-gp-insensitive ...
2009 NOV 16 ... catalyze oxidation at nucleophilic, heteroatom centers and are important for drug, xenobiotic, and endogenous substrate metabolism. In human liver, human FMO3 (hFMO3) is the most ...
2009 OCT 19 ... beta-hydroxysteroid dehydrogenase type 1 (HSD1) carbonyl reduction of cortisone and the xenobiotic triadimefon in hepatic microsomes. Our results demonstrate that the use of NADPH rather ...
2009 NOV 2 ... recently identified as a metastasis marker. The Hef1 gene induction is mediated by two xenobiotic responsive elements present in this gene promoter. Moreover, using RNA interference, we ...
2009 NOV 9 ... According to a study from Chongqing, People's Republic of China, "Pregnane xenobiotic receptor (PXR), a ligand-activated transcription factor, regulates the drug metabolism ...
2009 NOV 23 ... and pathways. Pathways related to oxidative stress response; lipid, glutathione, and xenobiotic metabolism; and the immune response were perturbed by the WD. Several nuclear ...
2009 NOV 9 ... sulfonating activity toward thyroxine and bithionol among a variety of endogenous and xenobiotic compounds tested as substrates. pH optimum of purified mouse SULT6B1 was determined to ...
2009 NOV 1 ... Huh7 cells formed complex, multilayered 3-D aggregates in which Phase I and Phase II xenobiotic drug metabolism genes, as well as hepatocyte-specific transcripts (HNF4 alpha, Albumin, ...
2009 NOV 16 ... resistance. If a cancerous cell's adaptation to therapy is achieved by upregulating xenobiotic metabolism or a redundant signaling pathway, the required investment in resources is ...
2009 NOV 9 ... "The liver is a major site for the metabolism of xenobiotic compounds due to its abundant level of phase I/II metabolic enzymes. With the cost of ...
2009 NOV 9 ... prevalence. The constitutive androstane receptor (CAR) was initially characterized as a xenobiotic receptor regulating the responses of mammals to xenotoxicants." "In this ...
2009 NOV 23 ... Scientists discuss in 'Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-hodgkin lymphoma' new ...
2009 OCT 19 ... cytochromes P450 3A (P450s 3A) are endoplasmic reticulum (ER)-proteins, responsible for xenobiotic metabolism. They are degraded by the ubiquitin-dependent 26S proteasome," scientists ...
